NF-kappaNeoplasms感染炎症模型There has been much effort recently to probe the long-recognized relationship between the pathological processes of infection, inflammation and cancer. For example, epidemiological studies have shown that approximately 15% of human deaths from cancer are associated with chronic...
NF-κB-responsive genes affect a diverse array of cellular processes including apoptosis and cell survival, and often directly control the course of a pathogen infection. In this review, we will examine signaling pathways leading to NF-κB activation during the innate immune response and mechanisms ...
Aim To study how Hcy leaded to NF-κB activation and induced endothelial inflammation and how simvastatin antagonized the inflammatory response. 方法同型半胱氨酸、辛伐他汀或两者联合处理人脐静脉内皮细胞不同时间点后,用核转录因子κB P65检测系统和凝胶电泳迁移率实验法检测κB P65核转录因子的活性,蛋白质...
Hyperammonemia is very toxic to the brain, leading to inflammation, disruption of brain cellular energy metabolism and cognitive function. However, the underlying mechanism(s) for these impairments is still not fully understood. This study investigated the effects of ammonia in hippocampal astroglia der...
NF-|[kappa]|B and STAT3 |[ndash]| key players in liver inflammation and cancer Cell death and differentiation is a monthly research journal focused on the exciting field of programmed cell death and apoptosis. It provides a single acc... G He,M Karin - 《Cell Research》 被引量: 1276...
Inflammation is recognized as one of the key characteristics of both preterm and term labour. There is accumulating evidence suggesting that NF-κB plays a significant role in the physiology of human labour. NF-κB has been shown to incr... S Kim,A Blanks,S Thornton,... - Archives of Dis...
The most common Rel/NF-κB dimer in mammals contains (p50)-RelA (p50/p65) heterodimers and is called NF-κB. The importance of Rel/NF-κB transcription factors in human inflammation and certain diseases makes them attractive targets for potential therapeutics.3↗,4↗,5↗ Synonyms Nuclear ...
Chronic inflammation is one of the primary causes of colorectal cancer (CRC), and major inflammatory pathways implicated in CRC are cyclooxygenase-2 (COX-2... Komal,Raina,Chapla,... - 《Molecular Carcinogenesis》 被引量: 72发表: 2011年 FGF-1-induced matrix metalloproteinase-9 expression in bre...
Atherosclerosis is a chronic inflammation course,NF κB,a kind of nuclear transcription factor,plays an important role. 动脉粥样硬化是一个慢性炎症过程 ,NF-κB在其中发挥重要作用。 3. During the early stage of reperfusion,DNA binding activities of NF κB in liver grafts were analyzed by EMSA(ele...
Three molecular clones of HIV-1, derived from a single isolate (AL1), exhibited distinct replicative and cytopathic properties during propagation in a human T cell line. The phenotypic differences observed were attributable, in large part, to changes affecting the viral LTR. Nucleotide sequence and...