InflammationTranscription FactorsNF-kappa BSignal TransductionI-kappa B KinaseResearch on the biological function of nuclear factor-kappaB (NF-kappaB), a key mediator of inducible transcription in the immune system, has traditionally focused on its role in the initiation of innate and adaptive immune ...
In this report, many of these aspects are discussed, giving particular emphasis in describing some biomarkers of inflammation. In particular, the data discussed in this report are based on an expert opinion derived on the findings from author’s studies on ageing, age-related diseases and inflamma...
In 1986, Ranjan Sen and David Baltimore first identified the nuclear factor in B lymphocytes binding to the kappa enhancer of the gene encoding the κ light- chain of immunoglobulin by electrophoretic migration assays of end-labeled DNA fragments and named it nuclear factor binding near the κ li...
In both animal models and human patients, the participation of neuroinflammation during MDD progression has been increasingly recognized. For example, Haapakoski et al. [61] discovered strong correlations between depression and the upregulation of peripheral markers of inflammation in CSF samples, such...
Collaborative efforts of physicians and basic scientists are often necessary in the investigation of complex disorders. Difficulties can arise, however, when large amounts of information need to reviewed. Advanced information retrieval can be beneficial
[3,54,102,103]. Furthermore, copper interacts with the Nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway, influencing inflammation and tumorigenesis. Elevated intracellular copper levels, induced by inflammatory cytokines, activate the XIAP, which in turn activates NFκB...
The release of pro-inflammatory cytokines relies on the activity of the transcription factor nuclear factor kappa B (NF-κB), which cooperates with co-activators, such as p300 and CREB-binding protein (CBP), containing histone acetyltransferase (HAT) activity, to activate gene transcription (Adcock...
Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal antibodies (MAbs) developed for cancer immunotherapy. Indeed, modulating immun
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being of the host. Recent studies have demonstrated that the GM may significantly influence bone metabolism and degenerative skeletal diseases, such as osteoporosis (
Cu2+, and Zn2+and chelating Fe2+[106] and limits the inflammation through the inhibition of NFkB [107]. It is an inducer of NRF2-mediated antioxidant gene expression and activates PPAR-α and –ɣ regulating the expression of several enzymes regulators of glucose and lipid metabolism [108...