Because of its crucial role in the regulation of pro-inflammatory genes, NF-κB is a promising target for the discovery of anti-inflammatory drugs. More recently, NF-κB has also emerged as a major culprit in a variety of human cancers mainly because of its ability to protect transformed ...
Transcriptional regulation via the NF-|[kappa]|B signaling module Stimulus-induced nuclear factor-kappaB (NF-kappaB) activity, the central mediator of inflammatory responses and immune function, comprises a family of dime... G Ghosh,A Hoffmann,G Natoli - 《Oncogene》 被引量: 1124发表: 2006年 ...
Current insights into the regulation of programmed cell death by NF-|[kappa]|B The nuclear factor-kappaB (NF-kappaB) transcription factors have emerged as major regulators of programmed cell death (PCD) whether via apoptosis or necros... J Dutta,Y Fan,N Gupta,... - 《Oncogene》 被引量:...
The property that gives NF-кB a widespread significance in cellular regulation is its role as a mediator of inducible gene transcription. The key features of NF-кB transcriptional control are that it is fast and versatile and is used in many different gene systems. It also has the ...
Transcriptional coactivator PGC-1a, acting via different transcription factors depending on different cell types, controls both the human and mouse ANT1 isoform genes though different mechanisms10. As a member of the mitochondrial carrier family (MCF) of proteins, ANT1 plays a key role in ...
As a result, in most cases NF-κB activation leads to transient upregulation of a number of genes encoding cytokines, growth factors, immunomodulatory molecules, apoptosis related genes and others. Prolonged activation of NF-κB has been reported in many pathological conditions of immune and ...
Hfq is an RNA-binding protein that functions in post-transcriptional gene regulation by mediating interactions between mRNAs and small regulatory RNAs (sRN... Y Noguchi,K Kamata,Y Dejima,... - 《Molecular Microbiology》 被引量: 14发表: 1995年 Brucella pneumonia with microabscess and pleural effu...
Hfq is an RNA-binding protein that functions in post-transcriptional gene regulation by mediating interactions between mRNAs and small regulatory RNAs (sRN... Y Noguchi,K Kamata,Y Dejima,... - 《Molecular Microbiology》 被引量: 14发表: 1995年 Brucella pneumonia with microabscess and pleural effu...
et al.; Polyadenylation in Rice Tungro Bacilliform Virus: cis-Acting Signals and Regulation, Journal of Virology (May 2001), vol. 75, No. 9, pp. 4184-4194. McQueen, Karina L., et al.; Functional analysis of 5′ and 3′ regions of the closely related Ly49c and j genes, ...
Luteolin and luteolin-7-O-glucoside protect against acute liver injury through regulation of inflammatory mediators and antioxidative enzymes in GalN/LPS-i... Anti-inflammatory and antioxidative activities of luteolin and luteolin-7- -glucoside were compared in galactosamine (GalN)/lipopolysaccharide (LPS...