Gene Expression RegulationNuclear Factor-Kappa B (NF-kappa B) was first identified by Sen and Baltimore (1986, Cell 46, 705-716) as a constitutively active transcription factor binding the kappa light chain immunoglobulin enhancer in B cells. Shortly afterwards, the same researchers found NF-...
NF-κB regulation in the immune system The nuclear factor-kappaB (NF-kappaB)/REL family of transcription factors has a central role in coordinating the expression of a wide variety of genes that... Q Li,IM Verma - 《Nature Reviews Immunology》 被引量: 6490发表: 0年 H2O2 and antioxidants ...
Verma NF-κB regulation in the immune system Nat. Rev. Immunol., 2 (2002), pp. 725-734 CrossrefView in ScopusGoogle Scholar [8] D. Li Selective degradation of the IkappaB kinase (IKK) by autophagy Cell Res., 16 (2006), pp. 855-856 CrossrefView in ScopusGoogle Scholar [9] V. ...
Li Q, Verma IM (2002) NF-kappaB regulation in the immune system. Nat Rev Immunol 2(10):725–734 CAS PubMed Google Scholar Liang N, Zhong Y, Zhou J, Liu B, Lu R, Guan Y et al (2018) Immunosuppressive effects of hydroxychloroquine and artemisinin combination therapy via the nuclear ...
Transcriptional coactivator PGC-1a, acting via different transcription factors depending on different cell types, controls both the human and mouse ANT1 isoform genes though different mechanisms10. As a member of the mitochondrial carrier family (MCF) of proteins, ANT1 plays a key role in ...
This suggests that Aged Garlic Extract supplementation benefits blood glucose regulation in diabetic animals when analyzed using an ITT approach (Fig. 4D). Fig. 4 A: Comparative Analysis of Blood Glucose Levels among Treatment Groups during IPGTT Intraperitoneal Glucose Tolerance Test (IPGTT) revealed ...
Recent prominent research efforts have shown that sphingosine 1-phosphate (S1P)/S1P receptor (S1PR) signaling is a crucial inflammatory mediator and is involved in pathogenesis of various inflammatory-related diseases [15]. In endothelial cells, upregulation of S1PR2 activates the ROCK/NF-κB pathwa...
Moreover, polysaccharides bind to the complement receptor type 3 (CR3)15. This receptor, expressed on immune cells, identifies polysaccharides16. When recognised, CR3 induces signalling to activate transcription factors. The major function of these transcription factors is inflammatory cytokine regulation....
The results indicate that hVICs treated with OM plus AGP exhibited decreased Alizarin Red S staining compared with cells treated with OM only in addition to down-regulation of ALP and RUNX2. Mappings of differentially expressed genes (DEGs) in different groups using Venn diagrams during analysis ...
The transcription factor NF-κB (nuclear factor kappa B) plays an important role in the transcriptional regulation of various genes involved in inflammation and immunological reactions. NF-κB is a homo- or heterodimer protein which belongs to the Rel family. In unstimulated conditions, NF-κB norm...