目前,炎症和肿瘤这一新兴领域研究已日趋成熟,炎症也已被广泛认可为肿瘤的标志和原因之一。2018年《Nature Review. Immunology》杂志上发表了题为《NF-κB, inflammation, immunity and cancer: coming of age》的综述,旨在探讨在将促肿瘤性炎症和肿瘤联系在一起的过程中,NF-...
[7] Guilherme A, Virbasius JV, Puri V, et al. Adipocyte dysfunc-tions linking obesity to insulin resistance and type 2diabetes. Nat Rev Mol Cell Biol 2008;9:367–77. [8] Peverill W, Powell LW, Skoien R. Evolving concepts in th...
CaMKII[delta]C is suggested to act as a link between inflammation and CH by regulating NF-kB. The results of the present study showed that although CaMKII[delta]B silencing was sufficient to prevent HSP60-induced cardiomyocyte hypertrophy, it did not decrease inflammatory cytokine IL-6 and TNF...
该句引用自:NF-κB, inflammation, immunity and cancer: coming of age(nature.com/articles/nri) 2024-05-06· 湖北 回复喜欢 Lori 作者 南风知我意 nature.com/articles/nri 2024-05-06· 湖北 回复喜欢展开其他 1 条回复 长夜长夜 帮助很大 感谢答主 2023-12-15· 重庆 回复...
of NF-κB signaling in inflammation and cancer. Mol Cancer. 2013;12:86. Published 2013 Aug 2.5. Beinke S, et al. Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J. 2004;382(Pt 2):393-409.6. Giridharan S, Srinivasan M. Mechanisms of NF-κB p65 and ...
[3]. Czerkies, M., et al., Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways. Nature Communications, 2018. 9(1).[4]. Sun, S., The non-canonical NF-κB pathway in immunity and inflammation. Nature Reviews Immunology, 2017. 17(9): p. ...
66: Proffered Paper: Regulation of NF-kB, inflammation and cancer by the E3 ligase RNF20The p53 tumor-suppressor plays a critical role in the prevention of human cancer. In the absence of cellular stress, the p53 protein is maintained at low steady-state levels and exerts very little, if...
Down-regulated cylindromatosis enhances NF-κB activation and aggravates inflammation in HBV-ACLF patients Emerging Microbes & Infections(IF:18) 研究发现下调的圆柱状瘤通过增强乙型肝炎病毒相关性急性慢性肝衰竭患者的NF-κB活化来加重炎性细胞趋化性,从而参与HBV-ACFL损伤的发病机制。 Zhang X, Zhang Y, Zho...
The NF-κB signaling pathway is a crucial regulatory mechanism in cellular responses to various stimuli, including inflammation, immune response, and cell survival. At the core of this pathway lies the transcription factor NF-κB, which plays a pivotal role in gene expression modulation. NF-κB ...
NF-κB, the ubiquitous nuclear transcription factor, plays a pivotal role in cellular responses to various stimuli across all animal cells. It is involved in inflammation, immune response, cell survival, synaptic plasticity, and memory formation. Notably, its dysregulation is implicated in...