Gray arrows indicate developmental events for which NF-kB plays no role or for which the role of NF-kB has not being clearly demonstrated. See the text for details.Hayden, M SWest, A PGhosh, SHayden MS, West AP, Ghosh S. NF-jB and the immune response. Oncogene 2006;25:6758-80....
The ancient origin of NF-kB/IkB and thioredoxin and their roles in immune response This thesis reports the discovery and characterization of a primitive but functional NF-kB/IkB cascade in a a??living fossila??, the horseshoe crab, demons... X Wang - 《Ph D》 被引量: 0发表: 2007年 ...
PU.1 is regulated by NF-kappaB through a novel binding site in a 17 kb upstream enhancer element. Oncogene 2010; 29:1062–1072. Article CAS PubMed Google Scholar Early SB, Huyett P, Brown-Steinke K, Borish L, Steinke JW . Functional analysis of -351 interleukin-9 promoter polymorphism...
In the aspect of RA,MALT1 not only may participate in its pathology viaregulating immune cells and inflammation (9–12), but alsopromotes RA development via a T-cell signaling dependentway and NF-kB signaling activ...
NF-kB与疾病的关系 1. 代谢性疾病的炎症基础: IKK / NF-kB信号通路是代谢,炎症和胰岛素作用之间联系的关键。无论是由细胞内还是细胞外线索引起的导致胰岛素抵抗或胰腺β细胞功能异常的大多数代谢应激信号都集中在NF-kB激活激酶IKKb和其他主要的炎性激酶JNK-促分裂原活化蛋白激酶(MAPK)上。
NF-kB is an inducible transcription factor that activates many cellular genes involved in stress and immune responseandwhoseDNAbindingactivityandcellulardistributionareregulatedbyIkBinhibitorproteins.The interaction between NF-kB p50 and DNA was investigated by protein footprinting using chemical modification an...
Incubation of lymphocytes with recombinant TNF-alpha revealed increased levels of NF-kB and p21 and reducted content of nonphosphorylated p53.TNF-alpha is a pleiotropic cytokine playing an important role in the regulation of immune response. One of the mechanisms of realization of this function by ...
NF-kB in Health and Disease Anurupa Dev, Shankar Iyer, Bahram Razani & Genhong Cheng Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 349)) 3678 Accesses 1 Altmetric Abstract Members of the NF-κB transcription factor family play a critical ...
非典型NF-kB信号通路在CEC的再生/分化过程中起着至关重要的作用。该通路通过一系列分子级联反应,特别是依赖于NIK的调控。当NIK缺失时,非典型NF-κB信号通路的功能将受到损害,进而影响CEC的正常发育与成熟。与之相比,典型NF-κB信号通路则主要参与调控炎症反应,而并非直接介入CEC的再生/分化过程,基于此,研究人员试图...
Our work thus defines an important function of non-canonical NFkB and M-cells in immune homeostasis, inflammation and polymicrobial sepsis.Similar content being viewed by others NRP1 instructs IL-17-producing ILC3s to drive colitis progression Article 01 January 2025 IκBζ controls IL-17-...