To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release. Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, lipid nanoparticle–mRNA ...
Lipid nanoparticles are essential to mRNA vaccines. The groundwork for lipid-based drug delivery systems was laid more than 40 years ago in the lab of Pieter Cullis, Professor at the University of British Columbia. Nature Reviews Materials talks to Pieter Cullis about the history and future of ...
Lipid Nanoparticles From Liposomes tomRNA Vaccine Delivery, a Landscape ofResearch Diversity and AdvancementRumiana Tenchov, Robert Bird, Allison E. Curtze, and Qiongqiong Zhou*Cite This: https://doi.org/10.1021/acsnano.1c04996 Read OnlineACCESSMetrics & More Article Recommendations * sı ...
Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs Article Nature Biomedical Engineering 06 October 2021 Access this article Log in via an institution Buy article PDF 39,95 € Price includes VAT (China (P.R.)) Instant access to the full article...
Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis 原文链接:https://doi.org/10.1073/pnas.2116271119 Significance 目前基于mRNA技术的应用主要局限于肝脏疾病,因为缺乏特异性和高效的肝外的体内mRNA递送系统。在这里,我们开发了一个n系列脂质纳米颗粒...
Pre-clinical and clinical studies have demonstrated that mRNA delivered intramuscularly (IM) with first-generation lipid nanoparticles (LNPs) generates robust immune responses. Despite progress made over the past several years, there remains significant opportunity for improvement, as the most advanced ...
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of the COVID-19 mRNA vaccines, LNPs play a key role in effectively protecting and transporting mRNA to cells. Liposomes...
Lipid nanoparticles (LNPs) represent the most clinically advanced mRNA delivery system with two marketed products, i.e., the COVID-19 mRNA vaccines Comirnaty® and Spikevax® from Pfizer/BioNTech and Moderna, respectively. In general, the LNPs used for mRNA delivery typically include four com...
(refs19,20) and BNT162b21, use lipid nanoparticles to deliver antigen mRNA. Many other lipid nanoparticle–mRNA formulations have been developed and are under clinical evaluation for the prevention and treatment of virus infections, cancer and genetic diseases7,8,9,10,11,12,13,14,15,16,17(...
Lipid nanoparticles for the inhalation of mRNARachel Yoon Kyung Chang & Hak-Kim Chan Nature Biomedical Engineering volume 5, pages 949–950 (2021)Cite this article 15k Accesses 46 Altmetric Metrics details Lipid nanoparticles can be optimized for the efficient delivery of mRNA via nebulization. This...