POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder, Skin changes) refers to a rare paraneoplastic entity linked to a plasma cell disorder, characterized by multiple systemic manifestations that must be studied together to establish a timely diagnosis. We report ...
Background Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic premalignant clonal plasma cell disorder. It is defined by the presence of serum levels of a monoclonal paraprotein lower than 3 g/dl, and a clonal plasma cell infiltration of the bone marrow less than 10%, ...
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma cell disorder present in 2.4% of the general population over the age of 50 years. MGUS is defined as the presence of a monoclonal protein <3.0 g/dL, <10% clonal plasma cells in the bone marrow, and absence o...
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking....
Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels...
Plasma cell dyscrasia with polyneuropathy and endocrine disorder: clinical and laboratory features of 109 reported cases. Jpn J Clin Oncol. 1983;13(3):543–55. CAS PubMed Google Scholar Nakanishi T, Sobue I, Toyokura Y, et al. The Crow-Fukase syndrome: a study of 102 cases in Japan...
monoclonal gammopathypathogenesisskinCutaneous manifestations of monoclonal gammopathy can precede, be concurrent with, or follow the onset of the plasma cell disorder. These manifestations may be classified as specific, resulting from direct infiltration of the skin by malignant plasma cells, or ...
and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder. ...
Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels...
Multiple myeloma (MM) is a clonal plasma cell (PC) disorder characterized by the presence of end organ damage such as lytic bone disease, anemia, hypercalcemia or renal insufficiency1. It is always preceded by an asymptomatic, pre-cursor phase known as monoclonal gammopathy of undetermined signifi...