The case of a 28-year-old female patient is presented.Heavy infiltration with plasma cells of uterine tissue removed by surgical curettage following an aborted pregnancy was detected by cytological and histological examination.Subsequent immunohistochemical studies revealed the monoclonal nature of these ...
In many cases, the MIg can be identified in the serum or urine by a conventional EP. However, in some cases, the MIg levels are very small and may not be detected by EP, likely reflecting the small size of the underlying B-cell clone and/or the affinity of the MIg for tissues and...
Monoclonal gammopathy of undetermined significance (MGUS) was identified in 3.2% of 21 463 residents of Olmsted County, Minnesota, 50 years of age or older... RA Kyle,BGM Durie,SV Rajkumar,... - 《Leukemia Official Journal of the Leukemia Society of America Leukemia Research Fund U K》 被...
Cerebrospinal fluid and serum of the patient showed a brain-restricted monoclonal lambda-light chain apparently produced by a small monoclonal immunoglobulin Glambda plasma cell population. In the preterminal stage, there was a systemic monoclonal gammopathy, the source of which could not be identified...
As treatment differs according to whether the clone has a plasmacytic or lymphocytic nature, choosing the right agent is challenging if a clone cannot be identified. Table 3 Renal lesions associated with monoclonal gammopathy Full size table Bone marrow aspiration and biopsy should be performed to ...
Two novel and simple methods have been developed for detecting monoclonal antibodies (MAbs) with identical epitope specificities from a large population of MAbs against human chorionic gonadotropin (hCG). The first method was based on the observation that following radioiodination many molecules of an ...
cell differentiation regulation of oligodendrocyte progenitor proliferation establishment of protein localization to plasma membrane negative regulation of canonical Wnt signaling pathway neuroligin clustering involved in postsynaptic membrane assembly neuronal stem cell population maintenance regulation ...
to high-analytical sensitivity, mass spectrometric assays also enable accurate follow-up of the identified M-protein as the molecular weight of the M-protein light-chain is a specific and reliable marker of the plasma cell clone. We studied a cohort of patients who were part of the Olmsted ...
PDCA-1 is predominantly expressed by IPCs in the naive mouse which represent sa very minor population (<0.5%) of splenocytes. It is upregulated on numerous cell types following stimulation which triggers an IFN response. PDCA-1 cycles between cell surface and intracellular compartments and may...
Peterson et al., “Biochemical and histological characterization of antigens preferentially expressed on the surface and cytoplasm of breast carcinoma cells identified by monoclonal antibodies against the human milk fat globule” (1990) Hybridoma 9:221-235. Posnett et al., “A novel method for pr...