Fig 1. CONSORT diagram demonstrating how the patient population of interest was determined for this case series. CPCMD, clonal plasma cell and myeloid disorders. 3. Results Eighteen patients were identified with concurrent CPCMD. Most patients had co-occurring MDS and MGUS and most disorders were...
Although our fate-mapping and parabiosis showed that incoming naive B cells contribute substantially to LLGCs at the population level, they did not distinguish between de novo establishment of new GC structures in empty follicular dendritic cell (FDC) niches and true invasion of ongoing GCs, as ac...
24,25,26,27and prior work has demonstrated that plasma cell contamination of peripheral blood (PB) stem product is generally minimal28,29. In order to confirm this, we performed ultra-low-pass whole-genome sequencing (ULP-WGS) on the stem cell products to detect large...
Cell population abundance: MED85 7500 cells with 25.9% positive for mesothelin and 97.7% positive for podoplanin. MED96 10000 cells with 17.4% positive for mesothelin and 55.7% positive for podoplanin. Gating strategy: samples were acquired first on FSC vs SSC and a generous gate created. ...
The CD19 Compartment in Myeloma Includes a Population of Clonal Cells Persistant After High-dose Treatment. 来自 EBSCO 喜欢 0 阅读量: 14 作者:Rasmussen,Thomas,Jensen,Linda,Johnsen,Hans,Erik 摘要: Investigates the persistence of circulating clonal CD19(+) cells in multiple myeloma (MM). ...
Bone marrow flow cytometric analysis is a powerful and rapid tool for evaluating plasma cell myeloma. By using a noncontrolled patient population in various stages of diagnosis and treatment, we compared 6-color (single-tube) and 4-color (multiple-tube) flow cytometric immunophenotyping protocols. ...
Of note, 4 discordant patients initially showed the same response to treatment and later developed divergent responses.Discussion Multiclonality in plasma cell neoplasms is a common occurrence, with a prevalence of 10% in our patient population. The use of SPEP and SFL as surrogate markers for ...
It has been described several years ago with a frequency below 20% in the general population and associated with a higher risk of myocardial infarction (MI) and stroke. Experimental data tend to show that the link between CHIP and atherosclerosis would mainly be mediated by a pro-inflammatory ...
Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder with a prevalence of 0.5% in the > 40 yrs population. Effort has been made... EQ Crusoe,AV Glasenapp,GN Ribeiro,... - 《Hematology Transfusion & Cell Therapy》 ...
Although historically considered a T cell-mediated disease, it is now well-known that an expanded, clonal population of plasma cells and B cells is involved in MS pathogenesis [33]. B cells are part of the adaptive humoral immune response, which is responsible for producing antigen-specific ...