The case of a 28-year-old female patient is presented.Heavy infiltration with plasma cells of uterine tissue removed by surgical curettage following an aborted pregnancy was detected by cytological and histological examination.Subsequent immunohistochemical studies revealed the monoclonal nature of these ...
Multiple myeloma is characterized by the proliferation of a monoclonal plasma cell population that essentially spreads in the bone marrow. However, immunological data and studies on clonal gene rearrangements have provided evidence for circulating malignant B-lymphocytes. Herein, we report on the ...
The term MGRS applies specifically to any B cell or plasma cell clonal lymphoproliferation with both of the following characteristics: One or more kidney lesions that are related to the produced monoclonal immunoglobulin The underlying B cell or plasma cell clone does not cause tumour complications ...
Introduction Monoclonal gammopathy of undetermined significance (MGUS) is a clinically asymptomatic premalignant plasma cell disorder. Previous studies in Western countries have described the prevalence of MGUS in Caucasians. However, data is limited in Chinese population. We therefore performed this study ...
means that there is an abnormal protein. Typically this protein can be detected during a physical examination and is identified using a screening blood test called “protein electrophoresis. The source of abnormal production of monoclonal antibody is a small population of plasma cells in the bone ...
Cerebrospinal fluid and serum of the patient showed a brain-restricted monoclonal lambda-light chain apparently produced by a small monoclonal immunoglobulin Glambda plasma cell population. In the preterminal stage, there was a systemic monoclonal gammopathy, the source of which could not be identified...
the monoclonal protein product of plasma cell, lymphocyte cell population is called as M-protein, monoclonal immunoglobulin (MIG) and paraprotein respectivelly ? clinical situations characterized by the occurence of an M-protein may be malignant or nonmalignant ? Laboratory evaluation of M-proteins ...
Produced by the same clone of plasma B cells. Production does not require hybridoma cell lines. Production requires hybridoma cell lines. A heterogeneous antibody population. A homogenous antibody population. Interact with different epitopes on the same antigen. Interact with a particular epitope on th...
In one third of all myeloma patients, the majority of B-cells was represented by monoclonal myeloma progenitor B-cells, whereas in two thirds of patients monoclonal cells only represented a small part of the entire B-cell population. As shown by sequence analysis, monoclonal precursor B-cells ...
1 The renal disease may complicate a previously diagnosed clonal B-cell disorder or be the initial manifestation of the hematological disease. Two main categories of renal disorders associated with monoclonal gammopathies should be distinguished, depending on the burden of the underlying plasma cell ...