Monoclonal BPC were detected in 16% (24/150) of patients. The median number of monoclonal BPC was 1脳106/l and 4.6% (7/150) of patients had a high number. The BLI was zero in all but three patients. This study demonstrates that monoclonal plasma cells circulate in the peripheral blood...
A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells... B Falini,M Fizzotti,A Pucciarini - 《Blood》 被引量: 0发表: 2013年 加载更多来源...
At 100% specificity, myelomas with proliferating plasma cells were more sensitively detected by the labelling index than by serum thymidine kinase (55% v 32% sensitivity). CONCLUSIONS--The labelling index represents a more specific and sensitive proliferation marker than serum thymidine kinase. Flow...
Establishment of a monoclonal antibody to plasma cells: a comparison with CD38 and PCA-1. Clin Exp Immunol. 1994; 96 :370–375... P Beckmann,JEO Mayne - 《Clinical & Experimental Immunology》 被引量: 6发表: 2008年 Establishment of five human myeloma cell lines. Regarding reaction with a ...
the plasma cell clone. We studied a cohort of patients who were part of the Olmsted County screening study to address this question. We hypothesized that a monoclonal protein can be detected with sensitive mass spectrometry assays in most patients several years prior to a diagnosis of clinical ...
It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the she...
It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the s...
Because many of these clones are best classified as MGUS, defined as a plasma cell proliferative disorder that manifests <3 g/dl of monoclonal protein and <10% bone marrow plasma cells, or smoldering MM, defined by >3 g/dl of monoclonal protein and/or >10% bone marrow plasma cells but...
Oncogenic drivers of progression of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) such as c-MYC have downstream effects on intracellular metabolic pathways of clonal plasma cells (PCs). Thus, extracellular environments such as the bone marrow (BM) plasma likely ha...
plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a ...