Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes (POEMS) syndrome is a rare condition defined by monoclonal plasma cell disorder, peripheral neuropathy, and other systemic symptoms. The pathophysiology of POEMS syndrome is unknown, but the overproduction of vascular endothelial...
Empty CellPlasma Cell DisorderMyeloid Disorder Age at Diagnosis (Years) 65 (33-82) 69 (51-85) Disease Type MGUS 12 CCUS 2 SMM 5 MDS 13 LCDD 1 MDS/MPN 3 Disease Risk MGUS by IMWG MDS or MDS/MPN by IPSS-M Low 2/13 Very Low 0/14 Low-Intermediate 7/13 Low 7/14 High-Intermediat...
Taken together, this study demonstrates that 6-color flow cytometry is an excellent, cost-effective means to assay for clonal plasma cells in a noncontrolled patient population. 展开 关键词: Plasma cell myeloma Multiple myeloma Flow cytometry ...
2.To create or propagate (an organism) from a clone cell:clone a sheep. 3.To reproduce or propagate asexually:clone a plant variety. 4.To produce a copy of; imitate closely:"The look has been cloned into cliché"(Cathleen McGuigan). ...
We have examined the role of membrane order (L o)/ disorder (L d) in antigen specific CD4 + T cell activation and clonal expansion by first creating membrane disorder, and then reconstituting membrane order by inserting cholesterol into the disordered plasma membrane. Significant revival of ...
Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder with a prevalence of 0.5% in the > 40 yrs population. Effort has been made... EQ Crusoe,AV Glasenapp,GN Ribeiro,... - 《Hematology Transfusion & Cell Therapy》 ...
while female patients have more robust T-cell activation, which is sustained in old age8. A B-cell autoimmune disorder present in about 10% of individuals with life-threatening COVID-19 pneumonia has been reported, 5 times more common in males than females, characterized by detection of neutra...
Ig intrathecal synthesis in MS results from plasma cell response and impaired immune T cell reaction, causing CNS inflammation, loss of myelin, and oligodendropathy. Igs are formed by combining a heavy chain (HC) and a light chain (LC). There are five HC subtypes (μ, δ, γ, α, and...
Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E: The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98: 365–376, 1999. CrossRef Mieda M. Willie JT, Hara J, Sinton CM...
reaction (PCR) can frequently be found in the blood of healthy individuals12 and follicular lymphoma in situ is a well recognized entity,13 it is extremely rare for CD5 −ve clinical MBL to show the immunophenotypic or genetic features of a germinal-center–derived clonal B-cell disorder.14...