POEMS syndrome is a rare paraneoplastic disorder due to an underlying clone of aberrant plasma cells. The name POEMS is an acronym for some of the major disease manifestations, namely polyneuropathy, organomegaly, endocrinopathy, presence of monoclonal component, and skin changes. The clinical ...
Fig. 1: After adrenaline stimulation, the expression of Trib1 in brown adipose increased. a The mRNA level of Trib1 in a variety of organs and tissues of normal C57BL/6J mice. b, c Lipid drop oil red staining and mRNA level of Trib1 in 3T3-L1 cells during adipogenesis. Scale bar: ...
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The blood of study participants, who were individuals licensed to apply restricted-use pesticides, was assessed for MGUS prevalence. The median age of participants was 60 years (range 30-94 years), and all lived in either Iowa or North Carolina. Participants also completed questionnaires providing ...
This chapter identifies the biological underpinnings, phenomenology, assessment and medical treatment of Autism Spectrum Disorder, a complex neurodevelopmental disorder. Basic science has made great strides in identifying the brain pathology of autism at various levels of scrutiny. This chapter reviews geneti...
Purkinje cell antibodies in a patient with cerebellar disorder: detection of responsible antigenic proteins A 34-year-old male patient developed a neurological disorder and signs of cerebellar degeneration, with antibodies against Purkinje cells in the serum, a s... JW Unger,PWM Reisinger,D Huppert...
Although GO analysis of these genes did not reveal any significant enrichment, Reactome pathway analysis found that their proteins were significantly enriched in the pathways of “Activation of AMPK downstream of NMDARs,”“Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane...
porphyria- a genetic abnormality of metabolism causing abdominal pains and mental confusion hepatolenticular degeneration,Wilson's disease- a rare inherited disorder of copper metabolism; copper accumulates in the liver and then in the red blood cells and brain ...
Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness. Transl Psychiatry. 2014;4:e428. https://doi.org/10.1038/tp.2014.72. CAS PubMed PubMed Central Google Scholar Liang M-H, Wendland JR, Chuang D-M. ...
cells (iPSC)-derived astrocyte progenitors, ketamine can exert rapid antidepressant effects through the activation of amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) glutamate receptors, and estrogen enhances this effect of ketamine by increasing the gene expression of AMPA receptor subunits...