Ginsberg A, Mullinax F: Pernicious anemia and monoclonal gammopathy in a patient with IgA deficiency. Amer J Med 48:787–791, 1970Ginsberg A, Mullinax F. Pernicious anemia and monoclonal gamm- opathy in a patient with IgA deficiency. Am J Med. 1970;48: 787-791....
and aSPEPis performed as part of the evaluation. In this latter scenario, a patient may have symptoms and signs, but when the evaluation is complete, none of these are attributed to the monoclonal gammopathy. To exclude other diagnoses, an extensive review of symptoms looking for sympt...
In Group II, a nonmalignant monoclonal gammopathy is strongly associated with cutaneous disease. This can be caused by deposition of all or part of the monoclonal immunoglobulin, autoantibody activity, cytokine-mediated, and by an unknown mechanism. Group III are miscellaneous cutaneous manifestations ...
T-cell large granular lymphocytic leukemia, monoclonal gammopathy of unknown significance and monoclonal B-cell lymphocytosis. The patient has only minimal complaints and has no anemia, neutropenia or thrombocytopenia. Lymphadenopathy and hepatosplenomegaly were not present. The three disorders were ...
monoclonal gammopathy of undetermined significance (mgus) is defined as presence of serum monoclonal protein at a concentration of 3 g per deciliter or less, no monoclonal protein or only moderate amounts of monoclonal light chains in urine, absence ofly
Multiple myeloma (MM) is a clonal plasma cell (PC) disorder characterized by the presence of end organ damage such as lytic bone disease, anemia, hypercalcemia or renal insufficiency1. It is always preceded by an asymptomatic, pre-cursor phase known as monoclonal gammopathy of undetermined signifi...
Monoclonal Gammopathy of Undetermined SignificanceAnemiaFemaleImmunoglobulin kappa-ChainsNo abstract is available for this article.doi:10.1111/j.1600-0609.2011.01584.xAnna MerinoServicio de Hemoterapia-Hemostasia, CDB;Servicio de Hematología Clínica, ICMHO, Hospital Clínic de Barcelona, IDIBAPS, Barcelona,...
入选标准 Inclusion Criteria: - Patients with either monoclonal gammopathy of unknown significance age >= 18 years old. - Both criteria must be met: - Serum monoclonal protein < 3 g/dL or urinary monoclonal protein < 500 mg per 24 hours and clonal bone marrow plasma cells < 10% - Absence...
monoclonal gammopathy of undetermined significance, through smoldering (asymptomatic) myeloma, to symptomatic MM.4 Clinically, symptomatic MM is characterized by end-organ damage, generally involving hypercalcemia, renal failure, anemia and bone marrow lesions (CRAB features).5 Skeletal pain and fatigue ...
MGUS requires that M-protein in serum is <30 g/l and that bone marrow clonal plasma cells are <10% with no evidence of other B cell proliferative disorders and no end organ damage (anemia, renal impairment, hypercalcemia, lytic bone lesions). 展开 ...