Monoclonal gammopathy of undetermined significance was diagnosed in one case. Although one patient with focal segmental glomerulosclerosis developed renal failure, all others exhibited stable renal function. Monoclonal IgG TBMID in the native kidney is not associated with renal prognosis. However, this ...
Monoclonal and polyclonal gammopathy measured by serum free light chain and immunofixation subdivide the clinical outcomes of diffuse large B-cell lymphoma according to molecular classification. Ann Hematol. 2014;93:1867–77. Article CAS PubMed Google Scholar de Leval L, Harris NL. Variability in ...
Monoclonal and polyclonal gammopathy measured by serum free light chain and immunofixation subdivide the clinical outcomes of diffuse large B-cell lymphoma according to molecular classification. Ann Hematol. 2014;93:1867–77. Article CAS PubMed Google Scholar de Leval L, Harris NL. Variability in ...
a homogeneous immunoglobulin resulting from the proliferation of a single clone of plasma cells; during electrophoresis of serum, it appears as a narrow band or "spike"; it is characterized by heavy chains of a single class and subclass and by light chains of a single type. ...
Related to Monoclonal antibodies: Polyclonal antibodiesmonoclonal antibody n. Any of the highly specific antibodies produced in large quantity by the clones of a single hybridoma cell. American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcou...
摘要: Hypergammaglobulinemia can result from both polyclonal and monoclonal immunoglobulin production. Polyclonal hypergammaglobulinemia is usually associated with inflammatory conditions and detected on serum protein electrophoresis (SPEP) as broad indistinct band. In contrast, monoclonal gammopathy is...
A polyclonal gammopathy is characterized by an increase in one or more heavy chains and in both types of light chain. One must differentiate between a monoclonal and a polyclonal increase in immunoglobulins, because a monoclonal increase is associated with a clonal process that is malignant or ...
We hypothesized that a polyclonal increase in serum free light chain may help to identify individuals at higher risk of developing a monoclonal gammopathy. We undertook this study in a population-based cohort who have been previously examined for the prevalence of MGUS to ascertain if increased poly...
The structure of immunoglobulins, relationship of normal (polyclonal) immunoglobulins to myeloma and macroglobulin (monoclonal) immunoglobulins, pattern of monoclonal immunoglobulin overproduction, and laboratory methods for the recognition and study of monoclonal proteins in the serum and urine are reviewed. ...
At diagnosis, the patient had a polyclonal increase of gamma-globulins. Five years after initial diagnosis, the patient presented with monoclonal gammopathy and infiltration of the bone marrow with neoplastic cells. Initially, the patient had received chemotherapy with different protocols (including ...