At low concentration, they most commonly represent monoclonal gammopathy of undetermined significance (MGUS), whereas high concentrations often signify plasma cell myeloma or B-cell lymphoma. However, several rare inflammatory conditions associated with variable concentrations of monoclonal proteins, systemic ...
Monoclonal Gammopathy of Clinical Significance (MGCS)Acquired von Willebrand SyndromeAcquired AngioedemaIntroduction Monoclonal gammopathies are common over the age of 50. Patients are usually asymptomatic. However, some patients present with secondary clinical manifestations, which are now grouped under the...
Monoclonal gammopathy of renal significance (MGRS) regroups all renal disorders caused by a monoclonal immunoglobulin (MIg) secreted by a nonmalignant B-cell clone. By definition, patients with MGRS do not meet the criteria for overt multiple myeloma/B-cell proliferation, and the hematologic ...
Monoclonal gammopathy MGUS: Monoclonal gammopathy of undetermined significance MM: Multiple myeloma PC: Plasma cell PID: Primary inherited immunodeficienc6y POEMS: Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, Skin Changes POEMS-MCD: POEMS-associated MCD PV: Polycythemia vera ...
Multiple myeloma (MM) is a highly heterogenous disease that exists along a continuous disease spectrum starting with premalignant conditions monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) that inevitably precede MM. Over the past two decades, significant pro...
The term monoclonal gammopathy of renal significance (MGRS) was introduced by the International Kidney and Monoclonal Gammopathy Research Group (IKMG) in 2012. The IKMG met in April 2017 to refine the definition of MGRS and to update the diagnostic crite
MONOCLONAL GAMMOPATHY of UNDETERMINED SIGNIFICANCE (MGUS) A. Benign (IgG, IgA, IgM, FLC kappa or lambda) B. Neoplastic diseases and conditions without usual presence of MIG C. ?Idiopathic“ Bence-Jones proteinuria ? or ? (MGUS ? or ?) II. MALIGNANT MG A. Symptomatic/Multiple myeloma (IgG...
Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic, premalignant clonal plasma cell proliferative disorder [1–4]. It was initially referred to as essential hyperglobulinemia by Jan Waldenström, as well as several other terms
The association of neuropathy with monoclonal gammopathy has been known for several years, even if the clinical and pathogenetic relevance of this association is not completely defined. This is not a marginal problem since monoclonal gammopathy is present in 1-3% of the population above 50 years in...
The accidental discovery of a monoclonal gammopathy (monoclonal protein or M protein, M spike) becomes increasingly common with advanced patient age, affecting approximately 3% to 4% of those over age 50, 5% over age 65 and almost 10% of those 85 or older. Since adult oncology practice is ...