Myeloma is the second most common hematological malignancy in adults in Western countries, and the malignancy is consistently preceded by a precursor state called monoclonal gammopathy of undetermined significance (MGUS). Myeloma is a genetically complex malignancy with a number of competing subclones ...
The neuropathies of Waldenstrm's macroglobulinemia (WM) and IgM-MGUS. Background: Neuropathy is common in Waldenstrm's macroglobulinemia (WM, an IgM-associated lymphoplasmacytic lymphoma) and in IgM-monoclonal gammopathy of undetermined significance (IgM-MGUS). Paraneoplastic or paraimmune mechanisms ...
and environmental aspects of fibromyalgia that may have an impact on its pathogenesis. Symptoms of fibromyalgia may be related to aberrations in the endogenous inhibition of pain as well as changes in the central processing of sensory input. Genetic research has revealed familial aggregation of fibromy...
Multiple myeloma (MM) is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. First described in 1848, MM is characterized by a proliferation of malign
L chain–type (AL) amyloidosis is related to both multiple myeloma and monoclonal gammopathy of undetermined significance (MGUS). These monoclonal plasma cell disorders can be categorized according to the total body burden of monoclonal plasma cells. When this burden is large, the diagnostic criteria...
57 Possible methods to overcome the formation of resistance could involve the combination of BAFF inhibitors with existing drugs such as proteasome inhibitors or IMiDs. Alternatively, the use of BAFF-inhibitory drugs could be confined to very early stage MM or even monoclonal gammopathy of ...
Here, we provide a comprehensive review of the latest advances in the study of MM pathogenesis, including the evolution of MM from monoclonal gammopathy of unclear significance. Bone marrow microenvironmental interactions are highlighted in the context of promoting proliferation, survival, drug resistance...
Whole-genome sequencing suggests a role of MIF in the pathophysiology of TEMPI syndromeTEMPI syndrome (telangiectasias, elevated erythropoietin level and erythrocytosis, monoclonal gammopathy, perinephric fluid collections, and intrapulmonary shunting) is a newly defined multisystemic disease with its ...
Moreover, treating the above murine model of GD with eliglustat led to a reduction of clonal Ig. The glucosylsphingosine might mediate B-cell activation in GD and might indeed be the antigenic origin of GD-associated monoclonal gammopathy. These new data give glucosylsphingosine a key role in ...
Serum chemistry: Elevation of lactate dehydrogenase levels correlates with tumor burden Liver function tests: Abnormal findings result from liver involvement Beta2-microglobulin: An elevated level indicates a poor prognosis Gamma globulin: Hypogammaglobulinemia or monoclonal gammopathy are rare findings ...