All patients had serum monoclonal IgM gammopathy (median, 2.6 g/L; range, 0.1-40 g/L). Overt hematologic malignancies were diagnosed in 16 patients (36%), with the most frequent being Waldenström macroglobulinemia (n = 9, 20%). Forty-one patients (91%) required treatment of CANOMAD. ...
Association of kappa light chain restriction with peripheral neuropathy among patients with non-IgM monoclonal gammopathy of undetermined significance. e20040 Background: Monoclonal gammopathy of undetermined significance (MGUS) can be associated with significant neurologic morbidity. Of non-IgM MGUS, type....
CIDP can occur with other systemic diseases such as diabetes mellitus (CIDP‐DM) and non‐malignant monoclonal gammopathy (CIDP‐MGUS). Whether I‐CIDP, CIDP‐DM and CIDP‐MGUS differ in clinical presentation, response to treatment and long‐term outcome is unclear, as well as the relationship ...
monoclonal protein- M-Protein&MGUS 06陆艺 Definition •M-proteinisamonoclonalimmunoglobulinsecretedbyanabnormallyexpandedcloneofplasmacellsinanamountthatcanbedetectedbyimmunofixationofserumand/orurine,or(rarely)otherbodyfluids(eg,jejunalfluidinalphaheavychaindisease),orbytheserumfreelightchainassay.•IgG,M,A,...
The IgM paraprotein is commonly a monoclonal gammopathy of undetermined significance (MGUS), but it may underscore also a lymphoproliferative disorder, most commonly Waldenstrom’s Macroglobulinemia (WM) but also marginal zone lymphoma or chronic lymphocytic leukemia (CLL). In these cases, the choice ...
Ahlskog MC, Kumar N, Mauermann ML, Klein CJ (2012) IgM- monoclonal gammopathy neuropathy and tremor: a first epi- demiologic case control study. Parkinsonism Relat Disord 18(6):748-752. doi:10.1016/j.parkreldis.2012.03.007Ahlskog MC, Kumar N, Mauermann ML, Klein CJ (2012) IgM-...
gammopathy of undetermined significanceAtaxia telangiectasia is an autosomal recessive neurologic disorder which is frequently associated with a deficiency of IgA immunoglobulin. We report an unusual case of monoclonal gammopathy of the IgA kappa type in a 2-year-old female patient newly diagnosed with ...
Monoclonal gammopathy of undetermined significance (MGUS) denotes the presence of a monoclonal protein (M-protein) in patients without evidence of multiple myeloma (MM), macroglobulinemia, amyloidosis (AL), or a related plasma cell proliferative disorder. MGUS is found in approximately 3% of persons ...
The presence of a monoclonal protein in the serum of a patient with peripheral neuropathy raises the suspicion of systemic amyloidosis, POEMS syndrome, macroglobulinemia, multiple myeloma, or lymphoma. If these conditions are excluded, the patient is classified as having a monoclonal gammopathy of ...
Monoclonal gammopathy of undetermined significance may be associated with many disorders, including lymphoproliferative diseases, leukemia, von Willebrand's disease, connective tissue diseases, and neurologic disorders. Epidemiologic and statistical methods must be used to evaluate these associations.Robert...