Systemic Lupus Erythematosus (SLE) as an autoimmune disorder, is characterized by a profound B cell activation, however, the association of this disease with a monoclonal gammopathy has been infrequently reporte
A monoclonal gammopathy precedes multiple myeloma in most patients. Blood 2009; 113: 5418–5422. 15 Tai YT, Chang BY, Kong SY, Fulciniti M, Yang G, Calle Y et al. Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in ...
The concept of monoclonal gammopathy of undetermined significance (MGUS) was first introduced in 1978 by Robert Kyle1. This premalignant condition is characterized by the presence of a serum monoclonal immunoglobulin <30 g/l and <10% monoclonal bone marrow plasma cells in a patient who does not...
Schnitzler syndrome (SchS) is a rare autoinflammatory disorder characterized by recurrent urticaria, monoclonal gammopathy, a fever, and arthralgia. We herein report a case of SchS complicated by rheumatoid arthritis (RA). A 78-year-old man presented to our hospital with a fever, myalgia, and...
At a cellular level, FHL2 is characterized by an excessive activation of CD8+ T cells. These hyperactive CTL are not able to kill their targets, but instead they secrete IFNγ; therefore, they efficiently activate macrophages, which can phagocytose blood components and infiltrate into different ...
Intermediate is smoldering multiple myeloma and benign is monoclonal gammopathy of undetermined significance. We hereby report a case of a 28-year male presented with fever of unknown origin (FUO) for 6 weeks. On examination he had pallor and mild jaundice; there was no hepato splenomegaly and ...
AL amyloidosis is characterized by amyloid fibrils formed of defective, abnormally folded monoclonal immunoglobulin LCs [47, 159, 160]. These identical LCs are produced at high levels by bone marrow derived plasma cell clones. The cause of AL amyloidosis in patients is still not fully understood ...
MM is a progressive disease that is preceded by an asymptomatic stage known as monoclonal gammopathy of undetermined significance (MGUS) and also often by an intermediate stage known as smoldering myeloma (SMM) [1,2,3,4,5]. Approximately, 15% of patients with MGUS and 10% with SMM will ...
Multiple Myeloma (MM) is an incurable hematological malignancy characterized by the proliferation of clonal, malignant plasma cells within the bone marrow (BM) [1]. Although precursor stages such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are read...
In normal serum, protein electrophoresis (SPE) yields a broad gamma fraction with Gaussian distribution due to the millions of plasma cell clones that secrete immunoglobulins (Ig) into the serum1. Polyclonal gammopathy is characterized by a broad diffuse increase of the gammaglobulin zone caused by...