blood disorders in the elderly is no exception. although the book is recently published and although most references are from within the past 5 years, many of the concepts explored are already dated. the chapter on myelodysplasia, for example, does not explore hypermethylation and histone ...
Landgren, O.et al. Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree relatives of 4458 patients with monoclonal gammopathy of undetermined significance in Sweden.Blood114, 791–795 (2009). ArticleCASGoogle Scholar Emery, A. E. H. Parental age and birth order. In: E...
Plasma cell (PC) dyscrasias are a heterogeneous group of blood disorders characterized by the detection of a monoclonal paraprotein in serum or urine, which is often associated with the presence of clonal PCs in the bone marrow (BM) and eventually other tissues.1With an estimated incidence of 6...
certain modifications of this protein pattern can be associated with specific pathological disorders. The modifications include the presence orabsenceof components, decreases or increases in intensity of components, or changes in microheterogeneity. The disorders included monoclonalgammopathies, hyper- and ...
Additional clinical applications for future exploration will include (i) monitoring and early detection of AL amyloidosis in plasma cell dyscrasias (monoclonal gammopathy of unknown significance, MM, and smoldering MM) and lymphoproliferative disorders, including LPL; and (ii) clinical management of ...
Exclusion criteria were as follows: (1) patients with extrapulmonary Mtb infection; (2) patients with diabetes mellitus, hyperlipidemia, and other metabolic disorders; (3) HIV-positive patients; (4) patients with co-infections; (5) patients with co-infections with other severe lung diseases; (6...
“hypertrophy” on echocardiography 10; hepatomegaly or increased alkaline phosphatase value with no imaging abnormalities of the liver; chronic inflammatory demyelinating polyneuropathy with a monoclonal protein; or the presence of a monoclonal gammopathy in a patient with unexplained fatigue, edema, ...
and very high concentrations ofIgGcan also cause hyperviscosity. Clinically significant serum hyperviscosity is almost invariably caused bylymphoproliferative disorders(e.g.,multiple myeloma,macroglobulinemia, lymphosarcoma; seeBox 12-2). Hyperviscosity syndrome rarely occurs ingammopathies(monoclonal or poly...
(BM1-122) and 66 from patients with hematological disease showing BM infiltration: 11 with Monoclonal Gammopathy of Undetermined Significance (MGUS) (BM123-133); 35 with Multiple Myeloma (MM) (BM134-168); and 20 with B-Cell Chronic Lymphoproliferative Disorders (B-CLPD) (6 Follicular Lymphoma...
However, the therapeutic efficacy of immunosuppressants is more significant, possibly related to cyclosporine directly stimulating hematopoietic cells or non-hematopoietic cells which secrete VEGF.[10] Others Thalassemia and sickle cell disease (SCD) are both genetic hemoglobin molecular function disorders ...