miR-541-3pSPOCD1Wn/tβ-catenin信号通路乳腺癌增殖迁移侵袭目的:探讨miR-541-3p对乳腺癌细胞的增殖,迁移,侵袭的影响及其作用机制.方法:将miR-con,miR-541-3p,anti-miR-con,anti-miR-541-3p,si-con,si-SPOCD1分别转染至MCF-7细胞中,分别记为miR-con组,miR-541-3p组,anti-miRcon组,anti-miR-541-3p组...
分别记为miR-541-3p+pcDNA-con组、miR-541-3p+pcDNA-SPOCD1组;转染均采用脂质体法.RT-qPCR检测miR-541-3p和SPOCD1 mRNA表达水平;Western blot法检测包含1个基因的SPOC结构域(SPOCD1)、细胞周期素D1 (CyclinD1)、基质金属蛋白酶2(MMP2)、基质金属蛋白酶9(MMP9)、β-连环蛋白(β-catenin)的表达;MTT检...
货号:mml-miR-541-3p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:mml-miR-541-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
货号:oar-miR-541-3p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:oar-miR-541-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
The TGIF2 was a direct target of miR-541-3p and promoted the growth and metastasis of NSCLC cells. Further study showed that TGIF2 could reverse the inhibitory effect of miR-541-3p on growth and metastasis of NSCLC cells. Taken together, our data highlight the pivotal role of miR-541-...
Heat shock protein 27 (HSP27), a regulator of cell survival, can enhance the resistance of cancer cells to radiotherapy. As microRNA-541-3p (miR-541-3p) was recently predicted to be a putative upstream modulator of HSP27, the present study was designed t
Non-small cell lung cancer Progression LINC00638 miR-541-3p Insulin receptor substrate 1 1. Introduction As one of the most prevailing malignancies across the world, lung cancer is the primary contributor to cancer-correlated mortality in men and women [1]. Non-small cell lung cancer (NSCLC) ...
miR-183, a member of an evolutionarily conserved miRNA cluster (miR-96, miR-182, and miR-183), has been demonstrated to act as both a tumor suppressor and oncogene in various type of human cancer. However, the biological role of miR-183 in gastric cancer (GC) still remains unclear. In...
STIM1 was confirmed to be a target gene of miR-541-3p in VSMCs. The knockdown of STIM1 significantly impaired the stimulatory effects of miR-541-3p knockdown on cell viability and migration. In conclusion, the findings of the present study suggested that miR-541-3p may efficiently repress ...
As microRNA-541-3p (miR-541-3p) was recently predicted to be a putative upstream modulator of HSP27, the present study was designed to investigate the function and mechanism underlying how miR-541-3p modulates the radiosensitivity of prostate cancer (PCa) cells by regulating HSP27. Through ...