miR-574-5p的用途,涉及生物医学材料小分子RNA.提供miR-574-5p在制备结直肠癌治疗药物和诊断试剂中的应用.miR-574-5p通过调控其靶基因Qki影响β-catenin/Wnt和p27Kip1信号转导,促进结直肠癌细胞的增殖,抑制结直肠癌细胞的分化,并促进结直肠癌细胞的迁移与侵袭.在结直肠癌细胞中,miR-574-5p表达异常升高,因此检测...
在第二方面的另一实施方案中,提供了一种用于在细胞或对象中抑制哺乳动物tlr7和/或哺乳动物tlr8介导的免疫应答的组合物,其包含针对mir-574-5p的shrna、与mir-574-5p互补的单链rna、靶向mir-574-5p的双链sirna、与mir-574-5p互补的单链dna;与mir-574-5p互补的单链rna、靶向mir-574-5p的双链sirna、和与mir-...
结果 与对照组比较,观察组血清miR-574-5p 表达水平(1.72±0.23 vs 1.04±0.17)升高,miR-138-5p 表达水平(0.55±0.08vs 1.02±0.16)降低,差异具有统计学意义(t=24.557,25.597,均P< 0.05);与预后良好组比较,预后不良组血清miR-138-5p 表达水平(0.41±0.06 vs 0.57±0.08)降低,miR-574-5p 表达水平(2.07±...
越来越多的证据指向miR-574-5p作为检测非小细胞肺癌的生物标志物:非小细胞肺癌患者血浆中miR-574-5p水平升高与肿瘤进展有关,癌细胞在细胞外小泡(sEV)中积极分泌miR-574-5p。但是miR-574-5p不仅仅是一个有趣的候选生物标志物。在异种移植小鼠模型中,mir -574-5p诱导的肺肿瘤生长被mPGES-1抑制剂化合物III (CII...
miR-574-5p is an unusual microRNA (miRNA) that is often upregulated or downregulated following exposure to irradiation or toxic chemicals; bacterial, parasitic or viral infection; and a variety of other disease conditions. Canonically, miR-574-5p epigene
miR-574-5p is an unusual microRNA (miRNA) that is often upregulated or downregulated following exposure to irradiation or toxic chemicals; bacterial, parasitic or viral infection; and a variety of other disease conditions. Canonically, miR-574-5p epigene
miR-574-5p in lupus patients and lupus-prone mice. Using qPCR analyses, we showed that in comparison with that of 18 normal subjects, serum miR-574-5p was significantly elevated in a cohort of 47 SLE patients (Fig.1a). Furthermore, the serum levels of miR-574-5p in the SLE patients ...
Serum miR-574-5p: a prognostic predictor of sepsis patients. Serum micro-RNAs (miRNAs) can be used for the diagnosis and prognosis of various diseases. Using genome-wide scans, we sought to identify serum miRNAs that... H Wang,K Meng,W Chen,... - 《Shock》 被引量: 127发表: 2012年...
miR-574-5p in lupus patients and lupus-prone mice. Using qPCR analyses, we showed that in comparison with that of 18 normal subjects, serum miR-574-5p was significantly elevated in a cohort of 47 SLE patients (Fig.1a). Furthermore, the serum levels of miR-574-5p in the SLE patients ...
(P<0.05);通过MTT实验筛选出曲马多的作用浓度为300μg/ml,以300μg/ml的曲马多处理胃癌细胞后miR-574-5p的表达水平显著降低(P<0.05);抑制miR-574-5p表达后可减弱胃癌细胞增殖能力,促进细胞凋亡,而miR-574-5p过表达后可逆转曲马多对胃癌细胞增殖及凋亡的作用.结论 曲马多通过下调miR-574-5p的表达抑制胃癌细胞...