MCE 国际站:hsa-miR-584-5p antagomir 产品活性:hsa-miR-584-5p antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链,全链进行甲氧基修饰,在5'端和3'端分别有2个和4个硫代骨架修饰,并在3'端连接有高亲和性胆固醇修饰。miRNA antagomir通过特异性结合成熟miRNA,阻止miRNA与其靶基因的互补配对,从而抑制miRNA...
1.miR-584-5p在作为急性呼吸窘迫综合征生物标记物中的应用。 2.如权利要求1所述的miR-584-5p在作为急性呼吸窘迫综合征生物标记物中的应用,其特征在于,所述的miR-584-5p具有如SEQ ID No.1所示的核苷酸序列。 3.如权利要求1所述的miR-584-5p在作为急性呼吸窘迫综合征生物标记物中的应用,其特征在于,所述的急...
Notably, we discovered that miR-584-5p imparts its tumor-suppressor and therapy-sensitizing effects by inhibiting histone deacetylase 1 (HDAC1), eukaryotic translation initiation factor 4e family member 3 (eIF4E3), and C-MYC. We demonstrated that miR-584-5p overexpression or the knockdown of its...
MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma 来自 科研支点 喜欢 0 阅读量: 45 作者:N Abdelfattah,S Rajamanickam,S Panneerdoss,S Timilsina,P Yadav,BC Onyeagucha,M Garcia,R Vadlamudi,Y Chen,A Brenner ...
•TheKLRG1rs1805672Gallele may increase susceptibility to pemphigus foliaceus.•A molecular mechanism is proposed forGallele-dependent miR-584-5p binding loss.•TheGallele abrogates reduction of reporter levels withKLRG13′UTR and miR-584-5p.•rs1805672 shows an expression Quantitative Trait Lo...
miR-194-5p是一种肾脏富含、且富集于人尿液外泌体的miRNA[3]。本研究旨在检测并分析miR-194-5p在儿童INS患者尿液外泌体中的变化趋势,评估其作为INS患儿辅助诊断标志物的临床价值。 1 材料和方法 1.1 研究对象 收集2017年2─11月在解放军东部战区总医院儿科确诊并住院的101例INS患儿治疗前尿液标本(晨尿),女26...
本发明公开了一种miR5845p在作为急性呼吸窘迫综合征生物标记物中的应用.本发明首次公开了miR5845p与急性呼吸窘迫综合征相关,本发明分析发现,miR5845p在正常血清,ARDS患者发病时的血清和ARDS患者死亡时的血清中的表达具有显著性差异,因此推断并验证了miR5845p能够作为ARDS的血清学生物标记物,可单独用来对ARDS患者进行...
Conclusion: CircABCB10 promoted the progression of NSCLC by modulating the miR-584-5p/E2F5 axis. Abbreviation: NSCLC: non-small cell lung cancer; circ RNA: circular RNA; miRNA: micro RNAdoi:10.1080/15384101.2020.1761617D. MaY. QinCheng Huang...
Conclusion CircSMYD4 prevents the development of HCC through regulating multiple signaling pathways such as metastasis and apoptosis by sponging miR-584-5p.doi:10.1186/s12935-020-01648-3Yanhe ZhangHui WangChao LiLinlin GaoXiaoguang ZhaoCancer Cell International...
The expression of miR‐584‐5p was decreased, and the expression of CDK16 was increased in HCC tissues and cell lines. Meanwhile, either knockdown of miR‐584‐5p or overexpression of CDK16 could suppress the HCC cell proliferation. In vivo, overexpression of miR‐584‐5p or ...