Collectively, these results suggest that the miR-574-5p-hTLR8/mTlr7 signaling is an important axis of immune and inflammatory responses, contributing significantly to the development of lupus and lupus nephritis.doi:10.1186/s12964-024-01601-1Wang, Tao...
Herein, we found that miR-574-5p, which was upregulated in both human and mouse lupus, acted as a potent ligand for mouse mTlr7 and human hTLR8 but not hTLR7. Aberrant activation of miR-574-5p-hTLR8/mTlr7 signaling was found to be associated with significant dysregulation in immune an...
miR-574-5p is an unusual microRNA (miRNA) that is often upregulated or downregulated following exposure to irradiation or toxic chemicals; bacterial, parasitic or viral infection; and a variety of other disease conditions. Canonically, miR-574-5p epigenetically regulates the expression of many messe...
miR-574-5p is an unusual microRNA (miRNA) that is often upregulated or downregulated following exposure to irradiation or toxic chemicals; bacterial, parasitic or viral infection; and a variety of other disease conditions. Canonically, miR-574-5p epigenetically regulates the expression of many messe...
We found that sEV-derived miR-574-5p activates Toll-like receptors (TLR) 7/8, thereby decreasing PGE 2 -levels. In contrast, intracellular miR-574-5p induces PGE 2 -biosynthesis. Consequently, the combination of intracellular and sEV-derived miR-574-5p controls PGE 2 -levels via a feed...
Abnormal miR-574-5p-TLR8/7 signaling has been shown to be tightly associated with inflammation-related cancers and a number of autoimmune disorders. miR-574-5p can serve as a potential biomarker for many diseases. Most importantly, miR-574-5p is a promising therapeutic...
Provided are the preventive or therapeutic uses of miR-574-5p, miR-574-5p mimics or derivatives, and miR-574-5p inhibitors as immune modulators, which exert actions through modulating TLR7 and/or TLR8 signaling. Also provided are compositions containing miR-574-5p, miR-574-5p mimics or ...
(0123456789) 182 Page 2 of 14 Clinical and Experimental Medicine (2024) 24:182 TLR Toll-like receptor TPs Time points Introduction In recent years, immunotherapy has emerged as a valid treat- ment option in different types of cancer, including non-small cell lung cancer (NSCLC) [1, ...
574-5p significantly ameliorates major symptoms associated with lupus and lupus nephritis. Collectively, these results suggest that the miR-574-5p-hTLR8/mTlr7 signaling is an important axis of immune and inflammatory responses, contributing significantly to the development of lupus and lupus nephritis....