MiR-543 suppressed BC cell malignancy. • VCAN was a target gene of miR-543. • The low expression of VCAN blocked BC cell malignancy caused by miR-543 inhibitor. Abstract Breast cancer (BC) continues to plague millions of people worldwide. MicroRNAs have been observed to be closely asso...
Moreover, miR-543 overexpression led to inhibition of viability, proliferation, migration, and invasion of breast cancer. Furthermore, miR-543 overexpression undermined the UBE2T promotional effect by inhibiting ERK/MAPK pathway activity in breast cancer cells. Our study revealed that miR-543 impaired...
摘要 探究宫腔黏连宫腔镜术治疗后患者子宫内膜组织中miR-543、miR-135a表达及复发关系。方法:回顾性选取2017年9月-2019年9月本院收治的行宫腔镜术治疗的中、重度宫腔黏连患者78例,根据宫腔镜治疗1年后复发情况分为复发组23例、未复发组55例。采用实时荧光定量PCR法检测患者子宫内膜组织中miR-543、miR-135a表达...
We found that miR-543-3p can suppress the expression and function of GLT-1 in MPP+-treated astrocytes and MPTP-treated mice. Inhibition of miR-543-3p can rescue the expression and function of GLT-1 and relieve dyskinesia in the PD model, which suggests that inhibition of miR-543-3p ...
CORRECTION| JANUARY 18 2022 "The authors of the original article “Down-regulation of miR-543 expression increases the sensitivity of colorectal cancer cells to 5-Fluorouracil through the PTEN/PI3K/AKT pathway” (Biosci Rep (2019) 39(3),https://doi.org/10.1042/BSR20190249)would like to correc...
Results: miR-543 was found to be up-regulated in RCC cell lines. Further studies identified DKK-1 as a direct target of miR-543. Moreover, miR-543 overexpression suppressed the expression of DKK-1, and promoted cell proliferation, migration and invasion capacity, while knockdown of miR-543 ...
为了进一步明确MEG3通过靶向下调miR-543并上调PTEN对PANC-1细胞增殖、侵袭和EMT的作用机制,本实验进一步观察了细胞的生物学行为。qRT-PCR检测结果证实,相比于对照组,敲降miR-543可显著下调PANC-1细胞中miR-543的表达水平(t=9.009, P=0.006),而同时敲降MEG3或PTEN对miR-543的表达与对照组差异没有统计学意义(t1=...
货号:mml-miR-543-3p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:mml-miR-543-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
美国埃默里大学王晓南教授和东南大学附属中大医院王彬博士课题组在生物医学1区杂志《Theranostics》(2017IF: 8.537)上发表论文,文中发现肌肉靶向多肽修饰的外泌体携带miR-26a可改善CKD小鼠骨骼肌和心肌的胰岛素抵抗状态,进而改善骨骼肌的萎...
miR-34a是microRNA中较为明确的一种肿瘤抑制因子,研究发现miR-34a在胰腺癌干细胞、前列腺癌于细胞和胃癌干细胞的抑制中起着关键性作用,但miR-34a在乳腺癌干细胞中的作用尚待阐述。采用免疫磁珠分选CD44+CD24-的乳腺癌干细胞。应用miR-34a模拟物和抑制剂调控miR-34a在人...