straightforward, but the findings will fuel interest in radical new therapies that aim to slow or reveise the ageing process as a means of tackling age-related diseases such as cancer brittle bones and Alzhcimer's.The scientists drew on previous work by the Japanese Nobel laureate Prof Shiny ...
Tackling neurodegenerative diseases with genomic engineering: a new stem cell initiative from the NIH. Neuron. 2021;109:1080–3. Article CAS PubMed PubMed Central Google Scholar Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, et al. A reference human induced ...
Surprisingly, the expression of QRPT and NAD+ was significantly increased in the brains and colons of the CRS mice, which was not consistent with the current reports on neurodegenerative diseases and aging models [63, 64]. We suspect that these expression levels may pivot during early-stage ...
The principles of antibody therapy for infectious diseases with relevance for COVID-19. mBio. 2021;12:e03372–20. Article CAS PubMed PubMed Central Google Scholar Seixas AMM, Sousa SA, Leitão JH. Antibody-based immunotherapies as a tool for tackling multidrug-resistant bacterial infections....
Challenge models may be used to investigate this further. Compared to the control groups, all recombinant strains, except for those expressing S1–1 and S1–2, significantly induced TNF-α and IL-6 expression (Fig. 4A). In contrast, IL-10 was greatly stimulated in S1–3, followed by that...
The analysis of publically available microarray data of 13 human HCC collectives revealed considerable upregulation of TGF-β2 as compared to normal liver.Our study demonstrates upregulation of TGF-β2 in liver disease and suggests TGF-β2 as a promising therapeutic target for tackling fibrosis and...
The analysis of publically available microarray data of 13 human HCC collectives revealed considerable upregulation of TGF-β2 as compared to normal liver. Our study demonstrates upregulation of TGF-β2 in liver disease and suggests TGF-β2 as a promising therapeutic target for tackling fibrosis ...
Since GPR18 expression was present in CD68 positive areas of human atherosclerotic lesions (Fig. 1B), macrophage markers were monitored in murine lesions. Aortic root sections positive for CD68 were stained for M2 macrophages markers and showed low expression of the M2 marker CD206 and a highly...
This has created challenges in studying the pathogenesis of human-tropic viruses as experiments in NHPs are hampered by logistical, financial, and ethical concerns. This creates a pressing need for more tractable small animal models to study existing and emerging viral diseases. In the last few ...
Acinetobacter baumannii is increasingly refractory to antibiotic treatment in healthcare settings. As is true of most human pathogens, the genetic path to antimicrobial resistance (AMR) and the role that the immune system plays in modulating AMR during d