Cardiovascular and cerebrovascular diseases that result from atherosclerosis and hypertension account for a large proportion of morbidity and mortality in the United States. Females are generally less susceptibl
In general, perturbation of a particular activity of a multifunctional protein is more common than gross defects in its overall functions among human diseases caused by genetic disorders25,26,27. As for TOP2B, a number of germline missense mutations were identified as causative for human diseases....
An appreciation of how environmental pollutants act on our cells to produce deleterious health effects has led to advances in our understanding of the molecular mechanisms underlying the pathogenesis of chronic diseases, including cancer and cardiovascular, neurodegenerative and respiratory diseases. Here, ...
Moreover, another work by Wang et al. (2015) supports the idea that miRNAs can be used in diseases therapy, especially sepsis, when they administrate mesenchymal stem cell exosomes containing miR-223, which confer cardiac protection in septic mice. Overall, using miRNA-based therapies to ...
WASHINGTON, Aug. 1 (Xinhua) -- The U.S. researchers developed a new mouse model that acquires the microbes and pathogens of wild mice via surrogacy, which can effectively translate the research in mice into advances in human health.
As such, mice have greater amounts of meta- bolically active tissues (e.g., liver and kidney) and more extensive deposits of brown fat [6]. Furthermore, mice more readily produce reactive oxygen species than do humans, which is an important consideration when modeling human diseases ...
After the outbreaks of SARS in 2002 and MERS in 2012, the world experienced the coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 in 2020. Similar to SARS-CoV, SARS-CoV-2 appeared unexpectedly and spread throughout the world rapidly, with 56 623 643 confirmed cases and ...
Hand, foot and mouth disease (HFMD), a common contagious disease that usually affects children, is normally mild but can have life-threatening manifestations. It can be caused by enteroviruses, particularly Coxsackieviruses and human enterovirus 71 (HEV7
In addition, depressive participants (n = 25) were excluded by parental history of bipolar disorder, schizophrenia or other psychiatric disorders according to DSM-V, meanwhile, subjects suffering from chronic systematic diseases, including diabetes, cardiovascular disease, thyroid disease, cancer etc...
Humanembryonic stem cells(hESCs) are isolated from theinner cell massof pre-implantationblastocystsand are pluripotent,i.e.have the ability to differentiate into any cell type of the body, bringing great potential to model human development and diseases as well as a potential source of differentiate...