Translating translational research: mouse models of human disease. Cell Mol Immunol 2013; 10:373-4; PMID:23934028; http://dx.doi. org/10.1038/cmi.2013.19Burkhardt AM and Zlotnik A. Translating translational research: mouse models of human disease. Cell Mol Immunol 2013; 10: 373-374....
Chapter 21 – Mouse Models of Inherited Human Neurodegenerative DiseaseDuring the development of the central nervous system and the peripheral nervous system, most populations of examined neurons are found to lose some percentage of their members during the normal process of maturation. This ...
Mice are increasingly being used as models for the study of various human diseases. This is primarily because among mammalian modals, they are most amenable to genetic manipulations. As we attempt to understand the molecular mechanism of diseases, it is imperative that the genes involved in the ...
Cancer, poliomyelitis, Alzheimer's and Gaucher disease, a seemingly disparate array of disorders, have become the target of powerful genetic analysis and drug screening protocols, using mouse strains that have been genetically altered to serve as models for understanding the disease and for helping th...
Basic informationMore Product Name:Mouse Models of Human Disease Synonyms:Human disease mouse model CAS: MF: MW:0 EINECS: Mol File:Mol File Browse by Nationality Suppliers>Global suppliers Guangdong (2)Member(2)All (2) Please select the suppliers ...
A major limitation of current humanized mouse models is that they primarily enable the analysis of human-specific pathogens that infect hematopoietic cells. However, most human pathogens target other cell types, including epithelial, endothelial and mesenchymal cells. Here, we show that implantation of...
Mouse models of human genetic disease: Which mouse is more like a man?doi:10.1002/bies.950181209There has always been great interest in animal models of human genetic disease, and mice provide the largest number of examples. A mutation in the homologous gene in mice does not always lead to ...
PBMC + CD34+HSC Humanized Models Model Types The humanized mouse model of the local human immune system is particularly effective for short-term or high-throughput research. Currently, we have the following model types available: Cancer TypeCell Lines ...
and Mouse Genomic Project" have been finished, a number of new techniques,such as transgenic animal, gene knockout, gene knock in, genome analysis system for large-scale mutagenesis had dramatically increased our ability to clone new susceptible genes and create mouse models of human disease. In...
Early impairments to neurovascular coupling have been proposed to be a key pathogenic factor in the onset and progression of Alzheimer’s disease (AD). Studies have shown impaired neurovascular function in several mouse models of AD, including the J20-hAPP mouse. In this study, we aimed to inve...