hyperactive immune response, causing severe immunological injury. Existing rodent models do not recapitulate the sustained immunopathology of patients with severe disease. Here we describe a humanized mouse model of COVID-19 that uses adeno-associated virus to deliver human ACE2 to the lungs...
Immunodeficient mouse modelsMyeloid malignancyPre-clinical studiesHumanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to bridge the gap between pre-clinical testing of novel therapeutics and their clinical ...
Leverage our study design expertise and mouse clinical trial experience to mimic the heterogeneity of clinical immune phenotypes in a preclinical setting, providing confidence in your study results Looking For a T Cell Targeted Approach? Discover our PBMC Humanized Models ...
Conditional over-expression of human ACE2 mouse model: Both human ACE2 and murine ACE2 are expressed in this model. Strong promoters for human ACE2, so hACE2 expression level is higher; According to the clinical manifestations of the disease, tissue-specific expression may be performed at the...
Humanized Mouse Models of Clinical Disease 2017, Annual Review of Pathology: Mechanisms of Disease Advances and challenges in studying hepatitis B virus In vitro 2016, Viruses Genetic Dissection of the Host Tropism of Human-Tropic Pathogens 2015, Annual Review of Genetics View all citing articles on...
1) or Rag2 loci, accompanied by a targeted mutation at the interleukin-2 receptor γ-chain (Il2rg) locus, support greatly increased engraftment and function of human haematopoietic stem cells (HSCs) and peripheral-blood mononuclear cells (PBMCs) compared with previous immunodeficient mouse models....
To advance our understanding of disease mechanisms and drug development, there is a pressing need for full-length genomic DNA humanized mice. These models can faithfully replicate human gene expression patterns, regulations, and functional properties in a mouse model. However, replacing the entire geno...
drawback that conventional mice cannot replicate certain human diseases and are good tools for human disease model research. Therefore, the human-derived tumor tissue xenograft PDX mouse model can realize human-related safety and efficacy assessment of new drugs in animals, simulating human clinical ...
Humanized Mouse Models of Clinical Disease 2017, Annual Review of Pathology: Mechanisms of Disease Human hemato-lymphoid system mice: Current use and future potential for medicine 2013, Annual Review of Immunology Pathogenesis of the viral hemorrhagic fevers 2013, Annual Review of Pathology: Mechanisms...
A mouse mAb raised against gp350 and derived from the hybridoma cell line 72A1 was produced in 1980, and in the past decades it has been shown to neutralize EBV infection of B cells in vitro, prevent development of EBV-positive tumors in xenograft mouse models, and provide some passive imm...