Menalled, L.B., Chesselet, M.F., 2002. Mouse models of Huntington's disease. Trends Pharmacol. Sci. 23, 32-39.Brooks SP, Dunnett SB. Mouse models of Huntington's disease. Curr Topics Behav Neurosci. 2015; 22:101-133Menalled, L.B. and Chesselet, M.F. (2002) Mouse models of...
Enhanced striatopallidal gamma゛minobutyric acid (GABA) A receptor transmission in mouse models of huntington's disease Background Huntington''s disease (HD) is caused by a CAG repeat expansion in the huntingtin gene. This mutation leads to progressive dysfunction that is la... Perez‐Rosello,...
Experimental therapeutics in transgenic mouse models of Huntington’s disease. Nat Rev Neurosci. 2004; 5 :373–384. doi: 10.1038/nrn1386. [ Cross Ref ]Beal, MF, Ferrante, RJ (2004) Experimental therapeutics in transgenic mouse models of Huntington’s disease. Nat Rev Neurosci 5: pp. 373-...
Mouse Models of Huntington's Disease The identification of the mutation causing Huntington's disease (HD) has led to the generation of a large number of mouse models. These models are used to ... PP Farshim,GP Bates 被引量: 0发表: 2018年 Therapeutic effects of coenzyme Q10 and remacemid...
Disturbances in sleep/wake cycle are a common complaint of individuals with Huntington's disease (HD) and are displayed by HD mouse models. The underlying mechanisms, including the possible role of the circadian timing system, are not well established. The BACHD mouse model of HD exhibits ...
NeuroRx: The Journal of the American Society for Experimental NeuroTherapeutics Knock-In Mouse Models of Huntington's Disease Liliana B. Menalled PsychoGenics Inc., Tarrytown, New York 10591 Summary: Huntington's disease is an autosomal dominant neurodegenerative disorder that is characterized by ...
摘要: The identification of the mutation causing Huntington's disease (HD) has led to the generation of a large number of mouse models. These models are used to further enhance our understanding of the...DOI: 10.1007/978-1-4939-7825-0_6 被引量: 405 ...
In the brains of mice with Huntington disease (HD), the transcriptional repressor histone deacetylase 4 (HDAC4) colocalizes with mutant huntingtin to form cytoplasmic inclusions, according to research reported in PLoS Biology. Mielcarek et al. found that an HDAC4 knock-down in these animals ...
The identification of the mutation causing Huntington's disease (HD) has led to the generation of a large number of mouse models. These models are used to further enhance our understanding of the mechanisms underlying the disease, as well as investigating and identifying therapeutic targets for thi...
Researchers at the California Institute of Technology (Caltech) have shown that a highly specific intrabody (an antibody fragment that works against a target inside a cell) is capable of stalling the development of Huntington's disease in a variety of mo