In the last several years, scientists have made several breakthroughs in the area of HD research. With these advances, our understanding of the disease continues to improve.Australian Huntington’s Disease Association (nsw) IncGene
Since the late 1880s hereditary chorea is named Huntington's disease after George Huntington (1850-1916) (Fig. 1.1) who provided the classical description of adult onset of hereditary chorea in his essay "On chorea" from 1872. However, this publication was not the first clinical description of...
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes Cell, 72 (1993), pp. 971-983 Google Scholar [119] S.H. Orkin Reverse genetics and human disease Cell, 47 (1986), pp. 845-850 Google Scholar [120] F.S. Collins Positional ...
and/or death usually by 13 Huntington’s Disease Inheritance pattern: Autosomal dominant Cause: A mutation in HTT gene resulting from increased trinucleotide repeats; Abnormal huntington protein products accumulate in neurons Symptoms: Onset typically in thirties or forties,progressive brain deterioration ...
Neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and... Ilya,Bezprozvanny - 《Trends in Molecular Medicine》 被引量: 465发表: 2009年 Prolonged cortical relay time of long latency reflex and...
BackgroundUnbiased longitudinal studies are needed to understand the distributed neurodegenerative changes of Huntington9s disease (HD). They may also prov... NZ Hobbs,SMD Henley,GR Ridgway,... - 《Journal of Neurology Neurosurgery & Psychiatry》 被引量: 211发表: 2010年 Population Dynamics of the...
Parkinson's diseaseSummary This introductory chapter presents an overview of concepts covered in this book. The book focuses on the following progressive neurological conditions: Huntington's disease (HD), motor neurone disease (MND), multiple sclerosis (MS), and Parkinson's disease. Whilst there ...
Disorders of the basal ganglia such as Parkinson's disease and Huntington's disease, have received extensive empirical and theoretical attention with respect to experimental therapeutic interventions. Levodopa pharmacotherapy, the mainstay treatment for Parkinson's disease in combination with carbidopa, ...
Jeffrey H. Kordower
Huntington’s diseaseα-synucleinamyloidtauThe respective pro-and antiapoptotic functions of the transcription factors p53 and nuclear factor kappa B (NF- kappa B), and their potential impact on tumorigenesis and response to tumor therapy are well recognized. The capacity of the RelA(p65) subunit ...