Insight into the mechanisms controlling some of these trafficking events has come from two groups who have examined the role of theproteasecathepsin S. Usinggene disruptionof cathepsin S and cathepsin S active site-directed probes, cathepsin S was shown to play an important regulatory role in the...
NLRC5: A Key Regulator of MHC Class I Gene Expression MHC Class I MHC class Imolecules are composed of a polymorphic chain and a non-polymorphic invariantβ chain(B2M) linked by a noncovalent interaction.MHC class Igenes are categorized intoclassical (MHC class Ia)(HLA-A, -B, -C, seeGl...
Unraveling multiple MHC gene associations with systemic lupus erythe- matosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans. Am J Hum Genet 2012; 91: 778–793. 17 Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification ...
Whereas the first three are characterized by activation of specific transcription factors, the SCLC-I (inflamed) subtype is characterized by an inflamed gene signature, high expression of MHC class I (MHC-I) antigen presentation and shows the greatest benefit from addition of immunotherapy to ...
Denzin LK, Khan AA, Virdis F, Wilks J, Kane M, Beilinson HA, Dikiy S, Case LK, Roopenian D, Witkowski M, Chervonsky AV, Golovkina TV (2017) Neutralizing antibody responses to viral infections are linked to the non-classical MHC class II gene H2-Ob. Immunity 47:310–322 e7 ...
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Retinoic acid-inducible gene I signalling (RIG-I signalling). A signalling pathway that is activated by the interaction of viral RNA with the receptor RIG-I. Through the adaptor protein MAVS (also known as IPS1, VISA and CARDIF), these signals activate the transcription factors IRF3 and IRF7...
Due to their immunogenicity and frequency of expression, CTAs have been targeted during multiple cancer vaccine trials and ACT trials, using either CTL or TCR gene-modified T cells [149]. The function of CTAs remains largely unknown, although the MAGE-A family, containing 12 genes, has been ...
NLRC5 (NLR family, CARD domain containing protein 5) in the transcriptional regulation of major histocompatibility complex (MHC) class I and related genes... ST Chelbi - 《Advances in Immunology》 被引量: 2发表: 2017年 Class I transactivator, NLRC5: a central player in the MHC class I pat...
tar A and MHC class I chain related gene A ( MIC —A ) polymor— phisms in Swedish patients with cerv ical cancer[ J ] .Hum Immu- nol ,200 1,62 ( 10 ) :1153 —8. [ 5] Ortiz C,Cardemil L.Heat—shock responses in two leguminous ...