form a platform with helical walls. The walls form a groove in which the antigenic peptide, consisting usually of 8–10 amino acids, is anchored. The α3 domain and β2 microglobulin are homologous (derived from a common ancestral polypeptide by gene duplication) and are members of theimmunogl...
CIITA promoter I CARD-deficient mice express func- tional MHC class II genes in myeloid and lymphoid compartments. Genes Immun. 13:299-310. http://dx.doi.org/10.1038/gene.2011.86Zinzow-Kramer WM, Long AB, Youngblood BA, Rosenthal KM, Butler R, Mohammed AU, et al. CIITA promoter I CARD...
Next, we confirmed that FoxO1 positively regulates MHC-II genes by binding to the promoter region of Ciita gene, the master activator of multiple MHC-II genes. Loss of FoxO1 in TAMs resulted in reduced MHC-II expression. Furthermore, we used FoxO1 conditional knockout mice to show that ...
GO terms significantly enriched in ABC-DLBCL, but not in GCB-DLBCL, cells include MHC II complexes, regulation of immune responses and leukocyte activation. (b) GO terms enriched in FOXP1-induced gene sets (that is, genes downregulated by FOXP1 depletion). Both GCB- and ABC-DLBCL cells ...
This gene complex was originally identified as the B blood group. A total of 27 different haplotypes (B1-B29) were defined using alloantisera (Briles and Briles, 1982). The detection of variation within the chicken MHC-B is of great interest as this variation has been shown to be highly ...
Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell tolerance to self and to recognition of foreign antigens. Antig
An NLR protein, class II transact... TB Meissner,A Li,A Biswas,... - 《Proceedings of the National Academy of Sciences》 被引量: 248发表: 2010年 NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression. of the nucleotide-binding domain, leucine-...
E. gene flow (基因流动) 查看完整题目与答案 相关题目: 下列反应中不属于酯化反应的是( )A.CH3CH2OH+HO—NO2CH3CH2ONO2+H2O+3nH2O 查看完整题目与答案 对可逆反应4NH3(g)+ 5O2(g)4NO(g)+ 6H2O(g),下列叙述正确的是[ ] A. 达到化学平衡时,4v正(O2)= 5v逆(NO) B. 若单位时间内生...
of the closest gene(s) and allele(s) expressed in IMGT/3Dstructure-DB protein sequences and IG and TR variable domains, by comparison with the IMGT domain directory, and the display of amino acid differences. IMGT/3Dstructure-DB is queried through a user- ...
CIITA promoter I CARD-deficient mice express func- tional MHC class II genes in myeloid and lymphoid compartments. Genes Immun (2012) 13:299-310. doi:10.1038/gene.2011.86Zinzow-Kramer WM, Long AB, Youngblood BA, Rosenthal KM, Butler R, Mohammed A- U-R, Skountzou I, Ahmed R, Evavold ...