Once docked onto the enhanceosome, several lines of evidence demonstrate that CIITA coordinates the recruitment of factors that promote chromatin opening and transcription at MHCclass II genepromoters (Fig. 2). Severallysine acetyltransferasesenhancinghistoneacetylation(HATs) have been shown to interact wi...
Next, we confirmed that FoxO1 positively regulates MHC-II genes by binding to the promoter region of Ciita gene, the master activator of multiple MHC-II genes. Loss of FoxO1 in TAMs resulted in reduced MHC-II expression. Furthermore, we used FoxO1 conditional knockout mice to show that ...
Individual MHC II genes were not significantly upregulated but are illustrated because of the importance of the overall pathway. (c) Scatter plot analysis of gene expression profiling (n = 41 000 probes) for FOXP1-silenced OCI-Ly3 (x axis) versus HBL-1 (y axis) cell lines with ± 1.41...
Plasmids containing EGFP alone or EGFP-tagged CD9 were introduced into A20 B cells growing in log phase by electroporation using a Bio-Rad GenePulser using a capacitance of 960 microfarads at 310 V. Cells were harvested after 72 h of transfection and analyzed for expression of CD9 by FACS...
Association between interleukin 17/interleukin 17 receptor gene polymorphisms and papillary thyroid cancer in Korean population. Cytokine. 2015;71(2):283–8. Article CAS Google Scholar Lauss M, Donia M, Harbst K, Andersen R, Mitra S, Rosengren F, et al. Mutational and putative neoantigen ...
(axicabtagene ciloleucel), another anti-CD19 CAR-T therapy, produced by Kite’s company, was approved to treat adult patients with R/R large B cell lymphoma [2,3]. The recent approval of these treatments has confirmed the dramatic effects of adoptive T cell therapy for the field of ...
(0.39–0.69) P-value 9.47 Â 10 À 27 9.56 Â 10 À 07 5.70 Â 10 À 06 Class Class III Class II Class II Gene BTNL2 DRB1-DQA1 DQB1-DQA2 OR (95% CI) 2.32 (1.98–2.71) 1.27 (1.09–1.49) 0.38 (0.29–0.50) P-value 2.02 Â 10 À 25 2.58 Â 10 À 03 ...
Retinoic acid-inducible gene I signalling (RIG-I signalling). A signalling pathway that is activated by the interaction of viral RNA with the receptor RIG-I. Through the adaptor protein MAVS (also known as IPS1, VISA and CARDIF), these signals activate the transcription factors IRF3 and IRF7...
The N-terminal domain of NLRC5 confers transcriptional activity for MHC class I and II gene expression J. Immunol., 193 (6) (2014), pp. 3090-3100 CrossrefView in ScopusGoogle Scholar Nussenblatt et al., 1982 R.B. Nussenblatt, et al. Birdshot retinochoroidopathy associated with HLA-A...
Henderson et al., “II Tumor Antigens Defined by Antibodies,” Advances in Immunology, 62: 217-256 (1996). Herman et al., “A peptide encoded by the human MAGE3 gene and presented by HLA-B44 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE3,” Immunogenetics, ...