MHC class Ⅰ chain-related gene alleles 5 and 5.1 are transmitted more frequently to type 1 diabetes offspring in HBDI families[J].Annals of the New York Academy of Sciences 2002,958.Zake, LN, Ghaderi, M, Park, YS, Babu, S, Eisenbarth, G, Sanjeevi, CB (2002) MHC class I chain-...
Gene conversion can create new MHC alleles. Immunological Reviews, 167, 305-318.Hogstrand K, Bohme J (1999). Gene conversion can create new MHC alleles. Immun Rev 167: 305-317.Hogstrand, K. and Bohme, J. (1999) Gene conversion can create new MHC alleles. Immunol. Rev. 167, 305-317...
while class II molecules are restricted to cells of theimmunesystem called macrophages andlymphocytes. In humans these molecules are encoded by several genes all clustered in the same region onchromosome6. Eachgenehas an unusually large number ofalleles(alternate forms of a gene that produce alternat...
As expected under DAA, the observed genotypes combined more sequence diversity than expected under a random association of alleles. Thus, DAA may contribute to maintaining MHC polymorphism, which is ancient, as supported by signatures of historical positive selection and trans-species polymorphism. Our...
现已证明,控制机体免疫应答能力与调节功能的基因(immune uesponse gene,Ir gene )也存在于MHC内。因此,MHC不仅与移植排斥反应有关,也广泛参与免疫应答的诱导与调节。不同种属的哺乳类动物其MHC及编码的抗原系统有不同的命名,小鼠的主要组织相容性抗原系统称为H-2系统,人的则称为人白细胞抗原系统(human leucocyte ...
HLA(humanleukocyteantigen):human’sMHCantigen,thegeneofitislocatedonchromosome6.H-2system:mouse’sMHCantigen,thegeneofitislocatedonchromosome17.Concepts •Majorhistocompatibilityantigen(MHCmolecules)•Majorhistocompatibilitycomplex(MHC,gene)•HLA(humanleukocyteantigen)•HLAgene Otherdiscovery •1960–1970，...
BACKGROUND: A large number of diseases occur in association with specific HLA-B or-C alleles. Recently a new gene, termed maj or histocompatibility complex class I chain-related gene A (MICA), has been identified in close proximity to HLA-B. The function of this gene is still unknown. Ho...
HLA的多态性现象乃由于下列原因所致:①复等位基因(multiple alleles):位于一对同源染色体上对应位置的一对基因称为等位基因(allele);由于群体中的突变,同一座的基因系列称为复等位基因。前已述及,HLA复合体的每一座均存在为数众多的复等位基因,这是HLA高度多态性的最主要原因。由于各个座位基因是随机组合的,故人群...
MHC-G gene in humans and other primates: The complete protein is not necessary for survival 来自 ResearchGate 喜欢 0 阅读量: 10 作者:A Arnaiz-Villena,MJ Castro,J Martinez-Laso,P Morales,L Allende 摘要: The generation of the B*41 alleles has been analysed using exon 1, intron 1, exon...
Centrocercus had no evidence for gene conversion at MHC class I. The occurrence of gene conversion was much more frequent across all class II sequences. In Centrocercus, 67% (8/12) of class II alleles had signatures of gene conversion (six significant pairwise gene conver- sions; ...