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通过建立并验证MDCKII-MDR1单层细胞体外药物转运模型,并以此细胞模型为工具,考察蛋白激酶C激动剂Phorbol-12-myristate-13-acetate(PMA)对P-gp介导的地高辛外排转运的... 黎玉华,毕惠嫦,钟国平,... - 全国临床药理学学术大会 被引量: 0发表: 2012年 蛋白激酶C激动剂对地高辛在MDCKII-MDR1细胞模型中转运的影响...
Permeability data from MDR1-MDCKII and PAMPA-BBB assays were compared to data from in situ brain perfusion to evaluate the accuracy of in vitro assays in predicting in vivo blood–brain barrier (BBB) permeability. PAMPA-BBB significantly correlated to in situ brain perfusion, however, MDR1-MDCK...
[J].BiolPharmacotherapy,2003,23:436—442. Pharm a1. Functional Bull.2006,29:2465—2471. S,Jain D,et [30]AgarwalR,Pal a1.Passive characterizationof inMDCKII—MDRl JE,WebsterLO,et [21]DoanKMM,Humphreys peptidetransporters and efflux celllineasamodelfororal J permeabilityP··glyeoprotein·...
描述: Inhibition of human MDR1-dependent accumulation of calcein-AM expressed in MDCK2 cells at 20 uM Format: BAO_0000219 Organism: Homo sapiens Cell type: MDCK-II Target: P-glycoprotein 1 (ALA4302) Document: ALA1153836 Inhibition of human MDR1-dependent accumulation of calcein-AM expressed...
Comparison of blood- brain barrier permeability assays: in situ brain perfusion, MDR1-MDCKII and PAMPA-BBB. J. Pharm. Sci. 98, 1980-1991.L. Di, E.H. Kerns, I.F. Bezar, S.L. Petusky, Y. Huang, Comparison of blood-brain barrier permeability assays: in situ brain perfusion, MDR1...
蛋白激酶C激动剂对地高辛在MDCKII-MDR1细胞模型中转运的影响研究 通过建立并验证MDCKII-MDR1单层细胞体外药物转运模型,并以此细胞模型为工具,考察蛋白激酶C激动剂Phorbol-12-myristate-13-acetate(PMA)对P-gp介导的地高辛外排转运的... 黎玉华,毕惠嫦,钟国平,... - 全国临床药理学学术大会 被引量: 0发表: 20...
蛋白激酶C激动剂对地高辛在MDCKII-MDR1细胞模型中转运的影响研究 通过建立并验证MDCKII-MDR1单层细胞体外药物转运模型,并以此细胞模型为工具,考察蛋白激酶C激动剂Phorbol-12-myristate-13-acetate(PMA)对P-gp介导的地高辛外排转运的... 黎玉华,毕惠嫦,钟国平,... - 全国临床药理学学术大会 被引量: 0发表: 20...
Verapamil displayed a vectorial basolateral-to-apical transepithelial efflux across the MDCK II MDR1 monolayers with a permeability of 5.7×105cmsec1 compared to an apical to basolateral permeability of 1.3×105cmsec-1. The efflux could be inhibited with the P-gp inhibitor zosuquidar. Zosuquid...
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