Using MDCK-MDR1 cells (a transfected cell line overexpressing human P-glycoprotein (multidrug resistance 1; MDR1)) to evaluate whether your compound is a substrate of the P-glycoprotein (P-gp) efflux transporter is crucial in early drug discovery/development as such knowledge feeds into both: ...
Liu, Y.; Zeng, S. Advances in the MDCK-MDR1 cell model and its applications to screen drug permeability. Yaoxue Xuebao 2008, 43, 559-64.Liu Y Zeng S.Advances in the MDCK-MDR1 cell model and its applications to screen drug permeability .药学学报,2008,:43-564,55...
关键词:MDCK-MDR1细胞;P-糖蛋白;药物转运;细胞模型中图分类号 :R965.1 文献标识码:A 文章编号:0513-4870(2008)06-0559-06收稿日期:2007-11-15.基金项目:浙江省科技厅重大项目重点资助项目(2005C13026).* 通讯作者 Tel/ Fax:86-571 -88208407,E-mail:zengsu@zju.edu.cnAdvancesintheMDCK-MDR1 cellmodel...
MDR1细胞;P一糖蛋白;药物转运;细胞模型 中图分类号:R965.1文献标识码:A文章编 号:O5l3—4870(2008)06—0559—06 AdvancesintheMDCK?MDR1cellmodelanditsapplications toscreendrugpermeability LIUYao,ZENGSu (CollegeofPharmaceuticalSciences,ZhangUniversity,Hangzhou310058, China) Abstract:Thisarticleintroducesthe...
as ofintestinal brainbarrierand therearesome inMDCK- mucosa,blood kidney.Although disadvantages MDRlcell isaneffectivetoolfor of inan fashion. model,it implementingpermeabilitydrug optimal words:MDCK-MDRl model Key cell;P—glycoprotein;drugtransport;cell 膜转运蛋白对药物的吸收、排泄及代谢,起着 (muhi...
This article introduces the characteristics and establishment of MDCK-MDR1 cell line, and its applications as an model for the assessment of the membrane p... 曾苏 - 《药学学报》 被引量: 0发表: 0年 应用MDCK-MDR1细胞模型研究3-乙酰基-11-羰基-b-乙酰乳香酸经血脑屏障的通透性 目的:考察3-乙...
suggesting that AKBA might not be the substrate of P-gp.[Key words] MDCK-MDR1 cell;blood-brain barrier;P-gp;apparent permeability coefficient血脑屏障(blood-brain barrier,BBB)是血液与脑组织、血液与脑脊液、脑脊液与脑组织 3 种隔膜的总称,是选择性地阻止各种物质由血入脑的屏障,有利于维持中枢神经...
The review summarizes the progress and applications of MDCK-MDR1 cell model. Because there is high polarized P-glycoprotein (P-gp) expression in MDCK-MDR1 cells, it could be used as a drug transport model to screen P-gp substrates or inhibitors, as well as models of intestinal mucosa, ...
摘要 本文介绍了MDCK-MDR1细胞系的特点、模型的建立,药物在其细胞模型上吸收转运的研究进展。概述了国内外关于利用MDCK-MDR1细胞系作为模型进行药物筛选、药物相互作用和研究药物吸收转运机制等方面的内容。MDCK-MD...展开更多 This article introduces the characteristics and establishment of MDCK-MDR1 cell line, ...
Although there are some disadvantages in MDCK2MDR1 cellmodel, it is an effective tool for implementing permeability of drug in an optimal fashion.Key words: MDCK2 MDR1 cell; P2glycoprotein; drug transport; cellmodel 膜转运蛋白对药物的吸收、 排泄及代谢 , 起着至关重要的作用。它可以保护细胞免...