Di L, Kerns EH, Bezar IF, Petusky SL, Huang Y (2009) Comparison of blood-brain barrier permeability assays: in situ brain perfusion, MDR1-MDCKII and PAMPA-BBB. J Pharm Sci 98(6):1980–1991Di, L., Kerns, E.H., Bezar, I.F., Petusky, S.L., Huang, Y., 2009. Comparison ...
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Verapamil displayed a vectorial basolateral-to-apical transepithelial efflux across the MDCK II MDR1 monolayers with a permeability of 5.7×105cmsec1 compared to an apical to basolateral permeability of 1.3×105cmsec-1. The efflux could be inhibited with the P-gp inhibitor zosuquidar. Zosuquid...
The study was to investigate the absorption mechanism and transport modulation of phillyrin by P-gp in Caco-2 cells and MDR1-MDCKII cells. Three concentrations of phillyrin were tested in transport studies. The absorptive transports of phillyrin in the two cell models were not concentration-...
Ketoconazole and the modulation of mul- tidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models. Xenobiotica 2008;38:107-129.Y. Fan, and R. Rodriguez-Proteau. Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 ...
This study investigates an in vitro model using P-gp expressing MDCKII-MDR1 cells for predicting in vivo brain drug penetration. Methods: In vitro equilibrium distribution studies were conducted in apical and basolateral solutions with high protein content to estimate Kp,brain and Kp,uu,brain ...
MDCKII-MDR1PermeabilityStabilityCo-amorphous mixtures have been demonstrated to represent a promising approach for enhancing the dissolution of poorly water-soluble drugs. However, little is known of their permeability properties, especially through biological membranes, or about the relationship between ...
Pharmacy sciences Effect of pharmaceuticals and natural products on multidrug resistance mediated transport in Caco-2 and MDCKII-MDR1 drug transport models OREGON STATE UNIVERSITY FanYingThis thesis details my investigation of some pharmaceuticals and naturalproducts on the transport of drugs which are ...
Polysorbates with one fatty acid chain decreased the efflux of digoxin through P-gp inhibition in MDCKII MDR1 cells. Mono- and di-saccharide-based surfactants, in a dose dependent manner, enhanced digoxin absorptive permeability without decreasing the secretory permeability in Caco-2 cells, ...
Evaluation of Drug Transport in MDCKII-Wild Type, MDCKII-MDR1, MDCKII-BCRP and Caco-2 Cell LinesIntroductionPathophysiology of Hepatobiliary SystemInborn Errors of Bile Acid/Salt Transporter DeficienciesDrugs and Cholestatic Liver DiseasePhospholipases and PhospholipidosisMechanisms of Toxicity Associated ...