Tumour-associated macrophages are an essential component of the tumour microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix remodelling, cancer cell proliferation, metastasis and immunosuppression, as well as in res
Macrophages as tools and targets in cancer therapy Article 16 August 2022 A timeline of tumour-associated macrophage biology Article 15 February 2023 The complex role of tumor-infiltrating macrophages Article 25 July 2022 References Zhang, Q. W. et al. Prognostic significance of tumor-associate...
TAMs express molecular triggers of checkpoint proteins that regulate T-cell activation, and are targets of certain checkpoint-blockade immunotherapies. Other macrophage-centred approaches to anticancer therapy are under investigation, and include: inhibition of macrophage recruitment to, and/or survival in...
Macrophages are known to be phagocytes of the innate immune system. They not only perform a defensive function against invading pathogens such as bacteria and viruses, but also help maintain immune homeostasis through the removal of apoptotic or necrotic cells in the body [1]. Macrophages take pa...
the knockdown of annex protein A2 (ANXA2) attenuated MMP28 induced M2 TAM polarization. Our findings suggest that MMP28 enhances TAM recruitment and M2 polarization by stimulating cytokine secretion through the MAPK/JNK pathway, providing novel insights into potential therapeutic targets for pancreatic ...
gondii infection, which may pave the way for exploring new targets for the prevention and control of toxoplasmosis as well as for the understanding of Toxoplasma–pig interactions. Methods Parasites and cells The T. gondii YZ-1 strain, isolated from a home-bred wild boar that succumbed to ...
Exosomes are naturally secreted nanovesicles that have emerged as a promising therapeutic nanodelivery platform due to their specific composition, biological properties, and stability. Modifying synthetic nanoparticles with the intrinsic hallmarks of exosome membrane to create exosome mimetics could lead to sa...
PROTAC-based drugs exhibit several benefits such as a wider range of action, improved selectivity, higher activity, and can target "non-generic" targets as well as overcome drug resistance. Compared with traditional occupancy-driven inhibitors such as JQ1, ARV-825 possesses high activity with only...
In recent years data have accumulated suggesting an important contribution of macrophages in the pathogenesis of IDDM, participating as primary inductor cells of autoimmunity, or as effector cells of B-cell destruction. In the spontaneously diabetic NOD mouse, macrophages and dendritic cells are the fi...
Laghi, and P. Allavena. 2017. Tumour-associated macrophages as treat- ment targets in oncology. Nat. Rev. Clin. Oncol. 14(7): 399-416.Mantovani, A., Marchesi, F., Malesci, A., Laghi, L. & Allavena, P. Tumour-associated macrophages as treatment targets in oncology. Nat. Rev. ...