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Accumulating scientific evidence has revealed that targeting macrophage phenotypes might be a potentially effective therapy in DFUs because hyperglycemia increases the ratio of proinflammatory M1 to pro-regenerative M2 macrophages. Th...
This review provides an in-depth look at FoxM1's involvement in controlling the actions of immune cells, particularly T cells, B cells, monocytes, macrophages, and dendritic cells, and its implications for disease processes.A stable cell cycle halt, typically in reaction to internal and/or ...
GSTP1 is widely expressed in human airways, predominantly in alveolar macrophages and epithelial cells [44]. Polymorphisms in the GST genes, such as GSPT1 (rs1695), affect the ability to respond to excessive oxidative stress by altering activity of the GST enzymes [45]. Based on the ...
the different responses of the two classes of lung macrophages could result in an overly aggressive immune response to normal triggering events. Indeed, he says, it would be the first step in a cascade that can end in inflammatory lung injury. "We may one day be able to target this upstrea...
Many children and young adults spend a lot of time on social media, much to the concern of their parents and guardians. Researchers at NTNU have now taken a closer look at the impact of using social media such as Instagram, Snapchat and TikTok on young people's mental health. ...
The researchers used water to flush out the noses and sinuses of the mice, and then looked at the inflammatory and other cells in the flushed-out fluid under a microscope. Sinuses of mice that inhaled polluted air. The sinus surface is breached as seen by the reduction in proteins that hol...