Accumulating scientific evidence has revealed that targeting macrophage phenotypes might be a potentially effective therapy in DFUs because hyperglycemia increases the ratio of proinflammatory M1 to pro-regenerative M2 macrophages. Th...
By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your perso...
The disease spectrum was found to be similar in patients around the world with macrophage activation syndrome associated with juvenile idiopathic arthritis, but treatment choices varied by region, according to the results of a study of 362 patients by 95 researchers in 33 countries.Patient data, inc...
It this test-tube system models what’s actually happening in the human lung, Holian told Science News, the different responses of the two classes of lung macrophages could result in an overly aggressive immune response to normal triggering events. Indeed, he says, it would be the first step...
by the macrophages, which promote their polarization into a pro-inflammatory state and transform into foam cells. The foam cells produce ceroids and destabilize the lysosomes and drive foam cell apoptosis, the remnants of which participate in fat deposition, with the released iron recycled to enter...
The researchers used water to flush out the noses and sinuses of the mice, and then looked at the inflammatory and other cells in the flushed-out fluid under a microscope. Sinuses of mice that inhaled polluted air. The sinus surface is breached as seen by the reduction in proteins that hol...
Leishmania donovani infections induce PGE2 generation within the host macrophages to aid in parasite survival [25]. PGE2 mediates immunosuppression that occurs in the acute phase of Chagas disease [26,27,28]. Anyona et al. [29] noted that the down regulation of PGE2 levels in Plasmodium ...