In contrast, inhibition of vascular cell adhesion molecule-1 had a minimal effect on leukocyte rolling, but significantly reduced both adhesion and emigration. These observations demonstrate that immune complex-mediated leukocyte recruitment in the cremaster muscle involves overlapping roles for the ...
Comparative neurovirulence in lentiviral infections: the roles of viral molecular diversity and select proteases. J Neurovirol 10 (Suppl 1): S113-S117.Power, C., Zhang, K., van Marle, G., 2004. Comparative neurovirulence in lentiviral infections: the roles of viral molecular diversity and ...
The central roles of IL-22 in the gut include maintaining normal barrier homeostasis, inducing the secretion of antibacterial proteins, and triggering the expression of chemokines for controlling the spread of invading pathogens [10]. However, IL-22 has both protective and pathologic roles, and the...
New Roles for Classical Immune Proteins Traditionally, the functions of classical immune molecules were thought to be restricted to the immune system. However, accumulating evidence demonstrates that some immune proteins contribute to neuronal function. Building upon these observations, McConnell et al. pr...
Varki, A. Biological roles of glycans. Glycobiology 27, 3–49 (2017). Article CAS PubMed Google Scholar Liang, R. et al. Polyvalent binding to carbohydrates immobilized on an insoluble resin. Proc. Natl Acad. Sci. USA 94, 10554–10559 (1997). Article CAS PubMed PubMed Central Google ...
a, Colocalization of UNC93B1 (red) and LAMP1 (green) in macrophages expressing the indicated UNC93B1 alleles using super-resolution structured illumination microscopy. Representative images are shown. Boxed areas are magnified. The plot shows quantification of the percentage of total UNC93B1 within...
Comparative neurovirulence in lentiviral infections: The roles of viral molecular diversity and select proteases. J NeuroVirol 10 ( Suppl 1 ): 113–117.Power C, Zhang K, van Marle G: Comparative neurovirulence in lentiviral infections: The roles of viral molecular diversity and select proteases....
This study elucidates the roles of TREM2 in human microglia-like HMC3 cells and the regulation of these functions by SH2-containing inositol-5′-phosphatase 1 (SHIP1). Using stable cell lines expressing wild-type TREM2, the R47H variant, and TREM2-deficient lines, we found that functional...
Because macrophages and T lymphocytes are important intermediates in LPS-induced eosinophil recruitment to the rat pleural cavity,32 an effect of antiselectin MoAbs on mononuclear cell influx may contribute to their inhibitory actions on eosinophil (and perhaps neutrophil) accumulation at 24 hours. An ...
Both the high-level biological roles of these genes as well as their extremely high age-dependent transcription differences strongly imply that such interactions may be of utmost importance for age-appropriate drug administration and should be duly acknowledged as VIPs. In addition, we identified ABCB...