However, the macrophage-targeted treatment of atherosclerosis remains elusive. Recently, macrophage-targeted gene therapy via lipid polymer nanoparticles (NPs) to improve the atherosclerotic plaque stability in mice was reported.doi:10.1016/j.matt.2020.08.009Yuan LiuXiaoyuan Chen...
Macrophage targeted therapy for AIDS: Regulation of monocyte differentiation with PA300, a novel oral form of MGBG that reverses CNS and myocardial disease in a SIV modelHIV associated neurocognitive disease (HAND) involves ongoing migration of blood associated monocytes into areas of disease. The ...
Macrophage-targeted photodynamic therapy (PDT) may have applications in the selective killing of cells involved in atherosclerosis, inflammation and tumor. We have previously shown that a conjugate between the photosensitizer chlorin(e6) (ce6) and maleylated bovine serum albumin (BSA-mal) gives highly...
Due to the complexity of tumors, combination therapy is typically needed to maximize an anti-tumor response. Thus, a clear understanding of the modes of drug action as well as mechanisms of resistance is needed in order to design an efficacious combination therapy that minimizes antagonistic ...
(epidermal growth factor receptor) is one of the most important receptors in this pathway and is a well known cancer therapy target. We therefore treated macrophages with a monoclonal antibody to EGFR prior to co-culture with CD4 T cells. The antibody prevented G0-G1 transition even in the ...
Redox biology of Leishmania and macrophage targeted nanoparticles for therapy 来自 Semantic Scholar 喜欢 0 阅读量: 15 作者:HS Sarwar,S Akhtar,MF Sohail,Z Naveed,M Rafay,A Nadhman,M Yasinzai,G Shahnaz 摘要: Intramacrophage parasite 'Leishmania' has developed various mechanisms for proficient ...
Correction to:Signal Transduction and Targeted Therapyhttps://doi.org/10.1038/s41392-024-02053-2, published online 13 December 2024 In the original version of this article,1the family names of second author Na Zhao was incorrectly published as “Zhou”, instead it should be “Zhao”. ...
While advanced genetic technologies, precise drug synthesis chemistry and controlled release systems have resulted in remarkable progress in the field of personalized medicine, gene and cell therapy; critical barriers – untargeted therapy, immune system defense & active non-invasive therapy monitoring – ...
(severe impairment is defined as eGFR ≤ 45 mL/min/1.73 m²). MPAA maintenance treatment is recommended after induction therapy. The guidelines also specify that azathioprine may be used as an alternative to MPAA for patients who are intolerant to MPAA, unable to obtain MPAA, or ...
2020). Current research has confirmed the use of salbutamol as an adjunctive therapy for SLE (Wulf and Ullman 2007). Therefore, further studies are needed to clarify the therapeutic effects of salbutamol in LN. Metformin Metformin can activate SIRT1 expression in macrophages, subsequently ...