For example, cytotoxic lymphocytes (CTL) such as CD8+ T and natural killer (NK) cells can recognize and eliminate cancer cells, and thereby restrict the tumour growth and metastasis, if they exert full cytotoxicity. In contrast, tumour-infiltrating myeloid cells such as tumour-associated ...
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Table 1 Advantages and disadvantages of anti-cancer therapies targeting macrophage behaviors Full size table Anti-angiogenic therapy Angiogenesis must occur in tumors for them to grow even small amounts [35]. This process can be influenced via a multitude of factors that are induced in hypoxic re...
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Therefore, gaining insights into the underlying mechanisms that control macrophage function in the tumor microenvironment is crucial for developing effective therapeutic interventions targeting macrophages in cancer. Notably, approaches that aim to reprogram TAMs towards an anti-tumor phenotype, such as by ...
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For example, erythrocyte membrane-camouflaged polymeric nanoparticles showed superior circulation half-life in mice [12]. Cancer cell membrane-coated nanoparticles demonstrated specific homologous targeting to cancer cells [13]. Platelet membrane-cloaked nanoparticles had selective adhesion to damaged ...
Targeting tumor-infiltrating macrophages limits progression and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma (PDAC). Protease-ac
Molecular imaging of vulnerable atherosclerotic plaques in vivo with osteopontin-specific upconversion nanoprobes. ACS Nano 11, 1816–1825 (2017). Article CAS PubMed Google Scholar Sun, X. et al. In vivo targeting and imaging of atherosclerosis using multifunctional virus-like particles of simian ...
Cancer immune therapy using engineered ‛tail-flipping’ nanoliposomes targeting alternatively activated macrophages ArticleOpen access04 August 2022 Polymeric nanocarrier via metabolism regulation mediates immunogenic cell death with spatiotemporal orchestration for cancer immunotherapy ...