Macrophage-targeted nanoparticle delivery systems. In: Svenson S, Prud'homme RK, editors. Multifunctional nanoparticles for drug delivery applications: imaging, targeting, and delivery., Lockwood DJ (Series Editor): Nanostructure science and technologyNew York: Springer; 2012. p. 47-84....
Targeted nanotherapeutics that can modulate plaque macrophage functions by the activation or suppression of specific signalling pathways have shown great promise in preclinical models by improving therapeutic efficacy and reducing off-target and systemic adverse effects. Rapid advances in nanotechnology and bio...
Vol. 45, No. 6, December 2022 ( 2022) #https://doi.org/10.1007/s10753-022-01692-3REVIEWMacrophage‑Targeted Nanomedicines for ARDS/ALI: Promise and PotentialRiddhi Vichare 1 and Jelena M. Janjic 1,2 Received
Macrophage-targeted photodynamic therapy (PDT) may have applications in the selective killing of cells involved in atherosclerosis, inflammation and tumor. We have previously shown that a conjugate between the photosensitizer chlorin(e6) (ce6) and maleylated bovine serum albumin (BSA-mal) gives highly...
Macrophage targeted therapy for AIDS: Regulation of monocyte differentiation with PA300, a novel oral form of MGBG that reverses CNS and myocardial disease in a SIV modelHIV associated neurocognitive disease (HAND) involves ongoing migration of blood associated monocytes into areas of disease. The ...
We have argued that local macrophage-targeted drug delivery is an important goal for drug delivery strategies to treat disease [28]; to this end, we have developed a monocyte-targeted delivery system based on a macrophage origin [29]. Here we extended this work by targeting visceral adipose ...
Macrophage-targeted CTP:phosphocholine cytidylyltransferase (1-314) transgenic mice. 来自 国家科技图书文献中心 喜欢 0 阅读量: 24 作者:T Wei,A Walsh,I Tabas 摘要: CTP:phosphocholine cytidylyltransferase (CT) is a rate-limiting and complexly regulated enzyme in phosphatidylcholine (PC) biosynthesis and...
Recent clinical data have shown that enzyme replacement therapy with macrophage-targeted glucocerebrosidase (GCR) can be effective in treating type 1 Gaucher disease. Sera from 262 patients, repeatedly infused with GCR, were assessed for the presence of antibodies to this therapeutic protein. Patient ...
Fig. 2: Development of macrophage-targeted, carbohydrate-coupled antimiR-21 (RCS-21). a Screening strategy to identify surface receptor genes that are enriched in macrophage populations compared to other cell populations in the lung (mRNA log2 fold change > 3 and FDR < 0.05) and are abu...
Previously we have reported the use of GPs for macrophage-targeted delivery of soluble payload macromolecules (i.e., proteins [23], DNA [24], and siRNA [25, 26]), and small drug molecules, such as the antibiotic rifampicin [27]. However, the use of GPs for small drug molecule delivery...