Macrophage-targeted nanoparticle delivery systems. In: Svenson S, Prud'homme RK, editors. Multifunctional nanoparticles for drug delivery applications: imaging, targeting, and delivery., Lockwood DJ (Series Editor): Nanostructure science and technologyNew York: Springer; 2012. p. 47-84....
et al. Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. Sci. Transl Med. 7, 275ra20 (2015). Article CAS PubMed PubMed Central Google Scholar Yurdagul, A. et al. Macrophage metabolism of apoptotic cell-...
These nanoparticles can accelerate bacteria-infected wound healing. In this work, nanoparticles were fabricated for bacteria-infected macrophage-targeted and microenvironment-responsive antibiotic delivery, cellular ROS generation, and proinflammatory up-regulation activity to eliminate intracellular bacteria, which...
All these results suggest that poly(lactic-co-glycolic acid nanoparticles functionalized with poly(zwitterion)-mannose brush grafts may be excellent candidates for targeted drug delivery to macrophages.Particle and Particle Systems CharacterizationStephanie ChristauAida López RuizNahal HabibiJudith WitteMark ...
The advantages of GP nanoparticle encapsulation include: (1) glucan receptor targeted delivery (2) the encapsulation of payload complexes that cannot be prepared in situ as the synthetic conditions are not compatible with glucan particles, (3) the loading of nanoparticles that can enhance the ...
Packaging an miR-125a-5p inhibitor or miR-221-3p mimic in RAW264.7 membrane nanoparticles has been shown to alleviate sepsis-induced ALI. Thus, we propose a method for screening functional EV micro-RNAs using multiomics-based analysis. Nanovesicles containing an miRNA mimic or inhibitor were ...
Targeted intracellular delivery of antituberculosis drugs to Mycobacterium tuberculosis-infected macrophages via functionalized mesoporous silica nanoparticles. Antimicrob Agents Chemother. 2012;56(5):2535–45. https://doi.org/10.1128/aac.06049-11. Article CAS PubMed PubMed Central Google Scholar Gaspar ...
Receptor-mediated targeted drug delivery to the macrophages by using nanoparticles emerges as promising strategy to improve therapeutic efficacy of old-fashioned drug. Receptor-mediated targeted nanoparticles can migrate across the cell membrane barriers and release enclosed drug cargo at sites of infection...
Nanoparticles provide distinct advantages for therapeutic application over traditional delivery methods by improving the targeted efficacy, pharmacokinetics, and bioavailability of the drugs being delivered. Functionalization of an active targeting motif creates opportunity and allows superior targeting of monocytes...
Macrophage-Targeted Nanomedicines Chapter© 2023 Understanding Macrophage-Associated Diseases and Applications of Nanodrug Delivery Systems Polymeric Nanoparticles-Assisted Macrophage Targeting: Basic Concepts and Therapeutic Goals 1Introduction Macrophages are vital cellular components of the innate immune system,...