Selective antagonism of CCR2, competitive inhibition of CCL2, and M2 macrophages plasticity modulation may shed light for future drug discovery and development to prevent and/or treat cardiovascular disease.doi:10.1007/978-3-030-84164-5_15Zhuqiu JinMacrophage Targeted Delivery Systems...
今天给大家分享一篇于2023年10月13日发表在Signal Transduction and Targeted Therapy(IF=39.3/Q1)的高分文章,题目为“Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression”,揭示了巨噬细胞介导心梗后心肌损伤的的新机制。 该研究工作由首都医科大学安贞...
Macrophage targeted therapy for AIDS: Regulation of monocyte differentiation with PA300, a novel oral form of MGBG that reverses CNS and myocardial disease in a SIV modelHIV associated neurocognitive disease (HAND) involves ongoing migration of blood associated monocytes into areas of disease. The ...
Macrophage-targeted photodynamic therapy (PDT) may have applications in the selective killing of cells involved in atherosclerosis, inflammation and tumor. We have previously shown that a conjugate between the photosensitizer chlorin(e6) (ce6) and maleylated bovine serum albumin (BSA-mal) gives highly...
As a result, the development of new therapies is very crucial, for example, targeted therapy, immunotherapy and electric field therapy. Studies over the past two decades have revealed that tumor microenvironment (TME) is a pivotal determinant of tumor behavior, and is responsible for tumor ...
Perspectives on TAM-targeted therapeutics With deeper understanding of cancer immunology, diverse strategies for modulation of TAMs are being uncovered and explored for therapeutic applications. Due to the complexity of tumors, combination therapy is typically needed to maximize an anti-tumor response. Thu...
However, due to the lacking specific targeting, it is difficult to deliver a sufficient amount of these agents to the damaged site by traditional delivery route without significant side-effects, thus effective therapy for SCI remains a great challenge. Recently, biomimetic-nanoparticle delivery systems...
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma in adults1,2. Combination therapy of rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) is potentially curative, but 30%–40% of cases relapse after initial therapy3. Elucida...
Advanced spray-dried design, physicochemical characterization, and aerosol dispersion performance of vancomycin and clarithromycin multifunctional controlled release particles for targeted respiratory delivery as dry powder inhalation aerosols. Int J Pharm. 2013;455(1–2):374–92. https://doi.org/10.1016/...
Macrophage-Targeted Therapy: CD64-Based Immunotoxins for Treatment of Chronic Inflammatory Diseases Diseases caused by chronic inflammation (e.g., arthritis, multiple sclerosis and diabetic ulcers) are multicausal, thus making treatment difficult and inef... D Hristodorov,R Mladenov,M Huhn,... -...