Ries CH, Cannarile MA, Hoves S, Benz J, Wartha K, Runza V, Rey‑Giraud F, Pradel LP, Feuerhake F, Klaman I, et al: Targeting tumor‑associated macrophages with anti‑CSF‑1R antibody reveals a strategy for cancer therapy. Cancer Cell 25: 846‑859...
However, the efficacy of immunotherapy remains suboptimal due to the impact of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs), a major component of the TME, play crucial roles in tumor invasion, metastasis, angiogenesis, and immune evasion, significantly impacting tumor ...
et al. Targeting tumor associated macrophages (TAMs) reprograms tumor immune microenvironment to promote solid tumor immunotherapy. Cell Oncol. 47, 2011–2014 (2024). https://doi.org/10.1007/s13402-024-00987-x Download citation Accepted23 August 2024 Published05 September 2024 Issue DateOctober ...
Tumor-associated macrophages (TAMs) play an important role in regulating tumor growth, invasion and metastasis, and constitute approximately 50% of tumor mass. TAMs can exist in two different subtypes, M1-polarized phenotype (pro-inflammatory and immunostimulatory) and M2-polarized phenotype (immunosuppr...
“M2” macrophages.32M2 and small populations of M1 cells, also known as tumor-associated macrophages (TAMs), have been generally thought to be involved in tumor initiation, progression, angiogenesis and metastasis.35Most relevant for patients, a high TAM infiltration is often correlated with poor...
Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and the immunosuppressive nature of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components of the TME. M2-like TAMs are essential in facilitating tumor me...
Targeting tumor-associated macrophages (TAMs) is a promising strategy to modify the immunosuppressive tumor microenvironment and improve cancer immunotherapy. Monoamine oxidase A (MAO-A) is an enzyme best known for its function in the brain; small molecule MAO inhibitors (MAOIs) are clinically used ...
For more information visit www.intechopen.com Chapter Targeting Tumor-Associated Macrophages by Plant Compounds Alice Grigore Abstract Macrophages play an important role in cancer development, as they represent almost half of the cells forming the tumor microenvironment. They are called tumor-associated...
Pharmacological inhibition of MCP-1 with bindarit also reduced tumor growth and macrophage recruitment, rendering necrotic tumor masses. We suggest that bindarit or Clod-Lip abrogates protumoral-associated macrophages in human melanoma xenografts and could be considered as complementary approaches to anti...
This document discusses the limitations of cancer immunotherapy using PD-1/PD-L1 immune checkpoint blockade (ICBs) and the importance of understanding the tumor immune microenvironment (TIME). The document focuses on the role of tumor-associated macrophages (TAMs) in solid tumors and their impact on...