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Interleukin 2,Interleukin 3,Interleukin 4,Interleukin 5,Interleukin 6,Granulocyte-macrophage colony-stimulating factor,Interferon-gamma Tumour necrosis factors Tumor necrosis factor (TNF, cachexin, or cachectin; often called tumor necrosis factor alpha or TNF-α) is an adipokine and a cytokine. TNF is...
Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway. Stem Cells 31, 248–258 (2013). Article CAS PubMed Google Scholar Marotta, L. L. et al. The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24...
Apart from the neoplastic cells, malignant tumours consist of the extracellular matrix (ECM) and normal cells, in particular tumour-associated macrophages ... COLLINS,T Harold - 《Carcinogenesis》 被引量: 110发表: 1973年 Alterations of mononuclear inflammatory cells, CD4/CD8+ T cells, interleukin ...
POSTN overexpression in CAFs is associated with many adverse clinicopathological factors, such as higher T and clinical stages and a larger tumor volume in NSCLC [72]; highly cell-rich and macrophage-infiltrated pancreatic cancer [73]; and lymph node metastasis and distant metastasis in pancreatic ...
(a) IL-6 blocks interferon (IFN)-γ mediated signaling; (b) IL-6 downregulates IL-6 receptor (IL-6R) expression in CD4 T-cells and is associated with T-helper cell depletion; (c) IL-6 induces IL-4 production; and (d) IL-6 is involved in macrophage and cytotoxic T-cell ...
Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J Neurosci. 1996;16:2352-2364. [PubMed] [Cited in This Article: 1] 198. Li J, Ma W, Wang S. Slower gastric emptying in high-fat diet induced obese rats is associated with attenuated ...
is to alter the chemical microenvironment shared between host and cancer cells in a way that no longer favours the latter. Ever since the first description of the Warburg effect, acidosis has been recognised as a key chemical signature of the tumour microenvironment. Recent findings have suggested...
A new control approach is promoter of the tumour necrosis factor α (TNF-α) gene40. the use of deltamethrine-treated collars, which reduced The gene encoding solute carrier family 11 A1 (SLC11A1; the risk of infection in dogs (by 54%) and children (by formerly NRAMP1), which ...
Reasons for susceptibility to poliovirus-associated disease remain unexplained but one favoured hypothesis is that the involvement of the central nervous system (CNS) is associated with a defect in type I IFN production, allowing robust poliovirus rep- lication in the periphery and spread of the ...