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Tumor-associated macrophage CRC: Colorectal cancer HCMB: Human cytomegalovirus G34R/V: Glycine 34 to arginine or valine RCC: Renal cell carcinoma MRCC: Metastatic renal cell carcinoma MNB: Multilayer network biomarker OPC: Oligodendrocyte precursor cell NPC: Nasopharyngeal carcinoma EGFR:...
Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway. Stem Cells 31, 248–258 (2013). Article CAS PubMed Google Scholar Marotta, L. L. et al. The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24...
While infiltration by macrophages is generally a poor prognostic factor in different types of cancer, in CRC it seems to be associated with a better prognosis[19], suggesting that antitumorigenic properties dominate in vivo. Adaptive immunity A specific antitumor response is generated by the adaptive...
(a) IL-6 blocks interferon (IFN)-γ mediated signaling; (b) IL-6 downregulates IL-6 receptor (IL-6R) expression in CD4 T-cells and is associated with T-helper cell depletion; (c) IL-6 induces IL-4 production; and (d) IL-6 is involved in macrophage and cytotoxic T-cell ...
This was associated with a significant (P < 0.001) decrease in macrophage tumour necrosis factor, superoxide anion and nitric oxide production compared with that in sham controls. Spontaneous bacterial translocation occurs in experimental obstructive jaundice and is associated with marked suppression of ...
1. Introduction Cachexia is a multifactorial syndrome characterized by body weight loss, declining muscle mass and function, wasting, and inflammation of adipose tissues accompanied by metabolic disarrangement, anorexia, systemic inflammation, and insulin resistance. Cachexia is typically...
In general, GISTs are heterozygous for a given mutation; however, in B15% of tumors the remain- ing wild-type KIT allele is lost and this is associated with malignant behavior.29,34–36 In serial samples from individual patients, Chen et al36 have provided evidence that this occurs through...
Reasons for susceptibility to poliovirus-associated disease remain unexplained but one favoured hypothesis is that the involvement of the central nervous system (CNS) is associated with a defect in type I IFN production, allowing robust poliovirus rep- lication in the periphery and spread of the ...
In the last 3 years, we have gained a wealth of experience with this and other immunotherapies in the clinical setting and learned a considerable amount regarding their potential benefit across multiple tumour types. CTLA-4 is a key inhibitory checkpoint molecule that is thought to counteract the...