However, tumor-associated macrophage, which are enriched in tumors, plays an important role in the development of GBM and is becoming a research hotspot for immunotherapy. This review focuses on current research advances in the use of macrophages as therapeutic targets or therapeutic tools for ...
review, we discuss macrophage functions in establishing distantmetastasesincluding formation of the premetastatic niche, extravasation ofcirculating cancer cells, and colonization of secondary metastases. A more thorough understanding of metastasis-associated macrophages and their associated mechanisms of ...
Tumor-associated macrophages (TAMs) are a prominent inflammatory cell population in many tumor types residing in both perivascular and avascular, hypoxic regions of these tissues. Analysis of TAMs in human tumor biopsies has shown that they express a variety of tumor-promoting factors and evidence fr...
Tumor-associated macrophage infiltration and prognosis in colorectal cancer: systematic review and meta-analysisCOLORECTAL cancerCANCER prognosisMETA-analysisPROGRESSION-free survivalBackground: Tumor-associated macrophages (TAMs) are key components of colorectal cancer (CRC) microenvironment, but their role in...
Recently, studies have indicated that M2-type macrophage resembling tumor-associated macrophages (TAMs) might be used as an independent prognostic factor for gastric cancer. This review will discuss the possible use of TAMs as prognostic tools for gastric cancer and whether they are suitable for use...
Transcriptional heterogeneity of tumor-associated macrophages (TAMs) has been investigated in individual cancers, but the extent to which these states transcend tumor types and represent a general feature of cancer remains unclear. We performed pan-cancer single-cell RNA sequencing analysis across nine ...
Tumor-associated macrophages (TAMs), one of the most abundant immune cell types in the tumor microenvironment (TME), account for approximately 50% of the local hematopoietic cells. TAMs play an important role in tumorigenesis and tumor development throug
associated with worse disease outcome [13,29]. However, classification and identification of TAMs should be correlated mainly to their function such as metastasis, angiogenesis, and immune regulation. Expression of CD68, CD14, HLA-DR, and CD204 have been used for macrophage classification, and ...
In progressive tumor, M2 tumor-associated macrophages (TAMs) are in the majority, being vital regulators reacting upon TME. This review elaborates on the role of TAMs in tumor progression. Furthermore, prospective macrophage-focused therapeutic strategies, including drugs not only in clinical trials ...
Macrophage–adipocyte crosstalk: drivers of malignant inflammation Examination into the influence of the tumor stroma has begun to elucidate the role of macrophage–adipocyte interactions in breast cancer development and progression.35Elevated body mass index (BMI) is associated with an increased risk of...