Mechanistically, our findings indicate that sleep deprivation facilitates the polarization of pro-tumoral macrophages by upregulating 尾2-adrenergic receptor (ADRB2), which subsequently enhances the expression of Kruppel-like transcription factor 4 (KLF4) through the JAK1/STAT6 phosphorylation pathway. ...
Tumor-associated macrophages In regular non-cancerous tissue, resident macrophages are responsible for maintaining homeostasis, prominently during infection and wound healing, through phagocytosis and inflammation regulation [8]. In the TME however, TAMs are highly abundant, and are predictive of outcome...
7. Researchers are investigating the protumoral properties of tumor-associated macrophages. - 研究人员正在调查与肿瘤相关的巨噬细胞的促肿瘤特性。 8. The identification of protumoral biomarkers could aid in cancer diagnosis and prognosis. - 促肿瘤生物标志物的识别可以帮助癌症的诊断和预后评估。 需要注意...
production and phagocytic activities of macrophages, and induced M2b polariza-tion. Further investigation showed that production of TNF-α and IL-1β was strongly inducedby TSP50 in TSP50-overexpressing cells. TSP50-induced TNF-α and IL-1β were main fac-tors that mediated the effects of TS...
In other immune cell types, PPARγ was shown to act as a master regulator of lipid metabolism in alveolar macrophages46, as inhibitor of pro-inflammatory cytokine secretion47, and to promote type-2 responses48. In that regard, Nobs et al. found that IL-33 drives Th2 responses and the ...
Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFsCell migrationGPCRsProtumoral bone marrow-derived cellsRhoGEFsRho GTPasesTie2-monocyte/macrophagesReciprocal communication among cells of the tumor microenvironment contributes to...
(MDSCs) and tumor-associated macrophages(TAMs). These cells promote tumor growth by several mechanisms, including their inherentimmunosuppressive activity, promotion of neoangiogenesis, mediation of epithelial-mesenchymaltransition and alteration of cellular metabolism. The pro-tumoral functions of TAMs and...
3b). On the other hand, E2B had no effect on the recruitment of macrophages(both F4/80+ CD11c− and F4/80+ CD11c+ macrophages)(Supplementary Fig. 2a). Figure 3: Estrogen promotes neutrophil recruitment during mammary tissue involution. Mice at 24 h post-weaning or age-matched ...
Identification of anti-/pro-tumoral macrophages in TNBC tumor specimens Tumor-infiltrating macrophages (Mφ) of all the conditions partitioned to two sub-clusters, respectively representing anti-tumoral Mφ and pro-tumoral Mφ. Previous studies revealed that in the macrophages against tumor cells, an...
of leukocytes in the tumor, a population of alternatively activated M2-like macrophages endowed with pro-tumoral functions such as: immunosuppression, promoting angiogenesis and cancer cell dissemination [32]. While classically activated, M1-like macrophages are pro-inflammatory (IL-12 high , TNF-...