M2-polarized macrophages are associated with immune suppressor cells harboring Myeloid derived suppressor cells, Regulatory T cells (Tregs), Regulatory B cells as well as alternatively activated (N2) neutrophils. Treg cells selectively support the metabolic stability, mitochondrial integrity, and survival ...
The non-malignant cells in TME contain cells such as tumor-associated macrophages (TAMs), cancer associated fibroblasts, pericytes, adipocytes, T cells, B cells, myeloid-derived suppressor cells (MDSCs), tumor-associated neutrophils (TANs), dendritic cells (DCs) and Vascular endothelial cells. ...
7. Researchers are investigating the protumoral properties of tumor-associated macrophages. - 研究人员正在调查与肿瘤相关的巨噬细胞的促肿瘤特性。 8. The identification of protumoral biomarkers could aid in cancer diagnosis and prognosis. - 促肿瘤生物标志物的识别可以帮助癌症的诊断和预后评估。 需要注意...
TSP50-induced TNF-α and IL-1β were main factors that mediated the effects of TSP50-overexpressing cells on macrophages. The NF-κB pathway could be activated in macrophages upon the treatment of conditioned medium of TSP50-overexpressing cells and its activation is necessary for the observed ...
研究成果:雜誌貢獻›文章›同行評審 5引文 斯高帕斯(Scopus) 摘要 Objective: This study aims to test the potential involvement of Axl signaling in the protumoral effect of tumor-associated macrophages (TAMs) in mucoepidermoid carcinoma (MEC). Materials and Methods: We carried out co-cultured...
(MDSCs) and tumor-associated macrophages(TAMs). These cells promote tumor growth by several mechanisms, including their inherentimmunosuppressive activity, promotion of neoangiogenesis, mediation of epithelial-mesenchymaltransition and alteration of cellular metabolism. The pro-tumoral functions of TAMs and...
(MDSCs)andtumor-associatedmacrophages (TAMs).Thesecellspromotetumorgrowthbyseveralmechanisms,includingtheirinherent immunosuppressiveactivity,promotionofneoangiogenesis,mediationofepithelial-mesenchymal transitionandalterationofcellularmetabolism.Thepro-tumoralfunctionsofTAMsandMDSCs arefurtherenhancedbytheircross-talk...
cancer stem cells; inflammation; tumor microenvironment; leukocyte reprogramming; tumor-associated macrophages; cancer-associated fibroblasts; regulatory T cells1. Introduction The presence of cancer stem cells (CSCs) has been confirmed in several tumors. They play a fundamental role in tumor development,...
Keywords: tumor-associated macrophages; myeloid-derived suppressor cells; inflammatory tumor microenvironment 1. Introduction In the first part of our review we summarize the current knowledge of the role of tumor-infiltrating immune cells in tumor pathogenesis. Briefly, while immune surveillance may ...
Kuniyasu H, Sasaki T, Sasahira T, Ohmori H, Takahashi T (2004) Depletion of tumor-infiltrating macrophages is associated with amphoterin expression in colon cancer. Pathobiology 71(3): 129–136. Kuniyasu H, Yasui W, Pettaway CA, Yano S, Oue N, Tahara E, Fidler IJ (2001) Interferon-...