M2-polarized macrophages are associated with immune suppressor cells harboring Myeloid derived suppressor cells, Regulatory T cells (Tregs), Regulatory B cells as well as alternatively activated (N2) neutrophils. Treg cells selectively support the metabolic stability, mitochondrial integrity, and survival ...
Tumor-associated macrophages In regular non-cancerous tissue, resident macrophages are responsible for maintaining homeostasis, prominently during infection and wound healing, through phagocytosis and inflammation regulation [8]. In the TME however, TAMs are highly abundant, and are predictive of outcome...
7. Researchers are investigating the protumoral properties of tumor-associated macrophages. - 研究人员正在调查与肿瘤相关的巨噬细胞的促肿瘤特性。 8. The identification of protumoral biomarkers could aid in cancer diagnosis and prognosis. - 促肿瘤生物标志物的识别可以帮助癌症的诊断和预后评估。 需要注意...
研究成果:雜誌貢獻›文章›同行評審 5引文 斯高帕斯(Scopus) 摘要 Objective: This study aims to test the potential involvement of Axl signaling in the protumoral effect of tumor-associated macrophages (TAMs) in mucoepidermoid carcinoma (MEC). Materials and Methods: We carried out co-cultured...
TSP50-induced TNF-α and IL-1β were main factors that mediated the effects of TSP50-overexpressing cells on macrophages. The NF-κB pathway could be activated in macrophages upon the treatment of conditioned medium of TSP50-overexpressing cells and its activation is necessary for the observed ...
(MDSCs) and tumor-associated macrophages(TAMs). These cells promote tumor growth by several mechanisms, including their inherentimmunosuppressive activity, promotion of neoangiogenesis, mediation of epithelial-mesenchymaltransition and alteration of cellular metabolism. The pro-tumoral functions of TAMs and...
摘要: Since the observation of Virchow, it has long been known that the tumor microenvironment constitutes the soil for the infiltration of inflammatory cells and for the release of infl... 查看全部>>关键词: tumor-associated macrophages myeloid-derived suppressor cells inflammatory tumor ...
of leukocytes in the tumor, a population of alternatively activated M2-like macrophages endowed with pro-tumoral functions such as: immunosuppression, promoting angiogenesis and cancer cell dissemination [32]. While classically activated, M1-like macrophages are pro-inflammatory (IL-12 high , TNF-...
Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFsCell migration, GPCRs, Protumoral bone marrow-derived cells, RhoGEFs, Rho GTPases, Tie2-monocyte/macrophagesReciprocal communication among cells of the tumor microenvironment...
In other immune cell types, PPARγ was shown to act as a master regulator of lipid metabolism in alveolar macrophages46, as inhibitor of pro-inflammatory cytokine secretion47, and to promote type-2 responses48. In that regard, Nobs et al. found that IL-33 drives Th2 responses and the ...