2012. Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like syno- viocyte and macrophage IL-6 production by accelerating mRNA decay. Ann Rheum Dis 71:424 - 431. http://dx.doi.org/10.1136/ard.2011.154211.Grabiec AM, Korchynskyi O, Tak PP, Reedquist KA: Histone ...
Keenan JA,Chen TT,Chadwell NL.IL-1 beta,TNF-alpha,and IL-2 in peritoneal fluid and macrophage-conditioned media of women with endometriosis[J].1995,34(06).Keenan JA,Chen TT,Chadwell NL. Interferon-Gamma(IFN-γ)and interleukine-6(IL-6) in peritoneal fluid and macrophage-conditioned media...
underlying this increased sensitivity is unknown. We investigated the possible involvement of macrophagesubpopulations as key mediators of HNSC radiosensitivity linked to HPV status. We collected forty-one clinicalHNSC specimens and determined HPV status and radiosensitivity of each sample. We investigated cy...
The survival rate was improved by the treatment of IL-6-deficient mice with a NO production-specific inhibitor. Our data revealed that IL-6 regulates the excessive release of NO through IL-1β inhibition and determines the establishment of an M2 macrophage profile within infected heart tissue. ...
enzymelinkedinmmnosorbentassay(ELISA)in32patientswithactiveAOSDpatients,26withstablediseaseand20healthyvolunteers.Results:Serum MIFandIL6levelsinpatientswithactiveAOSDweresignificantlyhigherthanthoseinstablediseaseandhealthycontrols(P<0.05).MIFlevelswere positivelycorrelatedwiththewhitecellcount(WBC),yetshowednocorrelati...
Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven synovitis exacerbates the pathological process. However, precise therapies for M1 macrophage to decrease synovitis and attenuate OA progression have been scarce
To examine whether Nrf2 directly binds to the M1-induced genes, we performed Nrf2 ChIP-seq analysis. In the M1-induced gene loci, Nrf2 binding was observed in the upstream regions of theIL6andIL1bgenes (Fig. 2a,b). Nrf2 binding was also detected in the downstream region of theIL1agene...
Importantly, however, blockade of IL-6 trans- signaling, unlike complete ablation of IL-6 signaling, does not exacerbate obesity-induced weight gain, liver steatosis, or insulin resistance. Our data identify the sIL-6R as a critical chemotactic signal for ATM recruitment and suggest that selectivel...
Macrophages, being the cornerstone of the immune system, have adapted the ancient nutrient acquisition mechanism of phagocytosis to engulf various infectious organisms thereby helping to orchestrate an appropriate host response. Phagocytosis refers to the process of internalization and degradation of particulat...
The inflammation was determined by measuring the levels of interleukin‐1 beta (IL‐1β), IL‐6 and tumour necrosis factor alpha (TNF‐α) using real time PCR, ELISA and immunohistochemistry. Exposure of cultured primary macrophages to VitB6 increased AMP‐activated protein kinase (AMPK) Thr172...